Wong G F, Gray C S, Hassanein R S, Koller W C
Department of Neurology, Kansas City 66103.
Arch Neurol. 1991 Mar;48(3):287-9. doi: 10.1001/archneur.1991.00530150055018.
To investigate possible risk factors in Parkinson's disease, we conducted a case-controlled study of 19 families having two or more siblings with Parkinson's disease. Demographic data were collected, including lifetime histories of places of residence; sources of drinking water; occupations, such as farming; and exposure to herbicides and pesticides. Rural living and drinking well water, but not farming and herbicide exposure, were significantly increased in 38 parkinsonians compared with 38 normal control subjects. A comparison of parkinsonian siblings with siblings with essential tremor revealed no differences in any risk factors for the years of shared environment. These data suggest that living in a rural environment and drinking well water are risk factors for Parkinson's disease and that the total life exposure to an environmental toxin may be more important than exposure in early life.
为了研究帕金森病可能的风险因素，我们对19个有两个或更多患帕金森病兄弟姐妹的家庭进行了病例对照研究。收集了人口统计学数据，包括居住地点的终生历史、饮用水来源、职业（如务农）以及接触除草剂和杀虫剂的情况。与38名正常对照受试者相比，38名帕金森病患者中农村生活和饮用井水的比例显著增加，但务农和接触除草剂则不然。帕金森病患者的兄弟姐妹与特发性震颤患者的兄弟姐妹相比，在共享环境的年份里，任何风险因素都没有差异。这些数据表明，生活在农村环境和饮用井水是帕金森病的风险因素，并且环境毒素的终生总暴露可能比早年暴露更为重要。
