Zorzon M, Capus L, Pellegrino A, Cazzato G, Zivadinov R
Department of Clinical Medicine and Neurology, University of Trieste, Trieste, Italy.
Acta Neurol Scand. 2002 Feb;105(2):77-82. doi: 10.1034/j.1600-0404.2002.1o040.x.
The aetiology of Parkinson's disease remains unknown, although both genetic susceptibility and environmental factors are considered putative contributors to its origin. We performed a case-control study to investigate the association of familial and environmental risk factors with Parkinson's disease (PD).
We studied 136 patients with neurologist confirmed PD and 272 age- and sex-matched controls, affected by neurological diseases not related to PD. The risk of developing idiopathic PD associated with the following familial and environmental factors: positive family history of PD, positive family history of essential tremor (ET), age of mother at subject's birth, rural birth, rural living, well water use, farming as an occupation, exposure to pesticides, head tremor, exposure to general anaesthesia and to ionizing radiations, food restriction, concentration camp imprisonment and smoking has been assessed by using univariate and multivariate statistical techniques.
In the conditional multiple logistic regression analysis, positive family history of PD (OR 41.7, 95% CI 12.2-142.5, P < 0.0001), positive family history of ET (OR 10.8, 95% CI 2.6-43.7, P < 0.0001), age of mother at subject's birth (OR 2.6, 95% CI 1.4-3.7, P=0.0013), exposure to general anaesthesia (OR 2.2, 95% CI 1.3-3.8, P=0.0024), farming as an occupation (OR 7.7, 95% CI 1.4-44.1, P=0.0212) and well water use (OR 2.0, 95% CI 1.1-3.6, P=0.0308) exhibited a significant positive association with PD, whereas smoking showed a trend toward an inverse relationship with PD (OR 0.7, 95% CI 0.4-1.1, P < 0.06).
We conclude that both familial and environmental factors may contribute to PD aetiology.
尽管遗传易感性和环境因素都被认为可能是帕金森病发病的原因，但帕金森病的病因仍不明确。我们开展了一项病例对照研究，以调查家族和环境风险因素与帕金森病（PD）之间的关联。
我们研究了136例经神经科医生确诊的帕金森病患者以及272名年龄和性别匹配的对照者，这些对照者患有与帕金森病无关的神经系统疾病。通过单变量和多变量统计技术评估了与以下家族和环境因素相关的特发性帕金森病发病风险：帕金森病家族史阳性、特发性震颤（ET）家族史阳性、受试者出生时母亲的年龄、农村出生、农村居住、使用井水、务农、接触杀虫剂、头部震颤、接受全身麻醉和电离辐射、食物限制、集中营监禁以及吸烟。
在条件多因素logistic回归分析中，帕金森病家族史阳性（比值比[OR]41.7，95%可信区间[CI]12.2 - 142.5，P < 0.0001）、特发性震颤家族史阳性（OR 10.8，95%CI 2.6 - 43.7，P < 0.0001）、受试者出生时母亲的年龄（OR 2.6，95%CI 1.4 - 3.7，P = 0.0013）、接受全身麻醉（OR 2.2，95%CI 1.3 - 3.8，P = 0.0024）、务农（OR 7.7，95%CI 1.4 - 44.1，P = 0.0212）和使用井水（OR 2.0，95%CI 1.1 - 3.6，P = 0.0308）与帕金森病呈显著正相关，而吸烟与帕金森病呈负相关趋势（OR 0.7，95%CI 0.4 - 1.1，P < 0.06）。
我们得出结论，家族和环境因素都可能与帕金森病的病因有关。
