Marttila R J, Rinne U K
Department of Neurology, University of Turku, Finland.
J Neurol Neurosurg Psychiatry. 1988 Mar;51(3):429-31. doi: 10.1136/jnnp.51.3.429.
The occurrence of Parkinson's disease and of essential tremor was examined in the parents and siblings of 52 Parkinson's disease patients with onset before the age of 45 years. The expected numbers of cases with Parkinson's disease or essential tremor were calculated according to the age and sex specific incidence rates of Parkinson's disease and essential tremor in the general population. Among the parents, there was one case of Parkinson's disease (expected 1.2), and 10 cases of essential tremor (expected 5.4); among the siblings there were two cases of Parkinson's disease (expected 0.7), and three cases of essential tremor (expected 5.3). The observed and expected incidence of Parkinson's disease or essential tremor were not significantly different. This does not support the inheritance of early-onset Parkinson's disease, or the association of Parkinson's disease with essential tremor.
对52例45岁前发病的帕金森病患者的父母及兄弟姐妹进行帕金森病和特发性震颤发病情况的调查。根据一般人群中帕金森病和特发性震颤的年龄及性别特异性发病率，计算帕金森病或特发性震颤的预期病例数。在父母中，有1例帕金森病（预期1.2例），10例特发性震颤（预期5.4例）；在兄弟姐妹中，有2例帕金森病（预期0.7例），3例特发性震颤（预期5.3例）。帕金森病或特发性震颤的观察发病率与预期发病率无显著差异。这并不支持早发性帕金森病的遗传，或帕金森病与特发性震颤的关联。
