Department of Andrology and Endocrinology, Katholieke Universiteit Leuven, Leuven, Belgium.
Osteoporos Int. 2010 Aug;21(8):1331-9. doi: 10.1007/s00198-009-1144-2. Epub 2009 Dec 15.
The influence of sex steroids on calcaneal quantitative ultrasound (QUS) parameters was assessed in a population sample of middle-aged and elderly European men. Higher free and total E(2) though not testosterone, were independently associated with higher QUS parameters.
The aim of this study was to investigate the association between QUS parameters and sex steroids in middle-aged and elderly European men.
Three thousand one hundred forty-one men aged between 40 and 79 years were recruited from eight European centres for participation in a study of male ageing: the European Male Ageing Study. Subjects were invited by letter to attend for an interviewer-administered questionnaire, blood sample and QUS of the calcaneus (Hologic-SAHARA). Blood was assessed for sex steroids including oestradiol (E(2)), testosterone (T), free and bio-available E(2) and T and sex hormone binding globulin (SHBG).
Serum total T was not associated with any of the QUS parameters. Free T and both free and total E(2) were positively related to all QUS readings, while SHBG concentrations were negatively associated. These relationships were observed in both older and younger (<60 years) men. In a multivariate model, after adjustment for age, centre, height, weight, physical activity levels and smoking, free E(2) and SHBG, though not free T, remained independently associated with the QUS parameters. After further adjustment for IGF-1, however, the association with SHBG became non-significant.
Higher free and total E(2) are associated with bone health not only among the elderly but also middle-aged European men.
本研究评估了性激素对中年和老年欧洲男性跟骨定量超声（QUS）参数的影响。游离和总雌二醇（E2）水平较高（但非睾酮）与 QUS 参数较高独立相关。
本研究旨在调查 QUS 参数与中年和老年欧洲男性性激素之间的相关性。
从欧洲 8 个中心招募了 3141 名年龄在 40 至 79 岁之间的男性参加男性衰老研究（European Male Ageing Study）。通过信件邀请受试者参加访谈式问卷调查、血液样本采集和跟骨超声（Hologic-SAHARA）检查。评估了包括雌二醇（E2）、睾酮（T）、游离和生物可利用的 E2 和 T 以及性激素结合球蛋白（SHBG）在内的性激素。
血清总 T 与任何 QUS 参数均无相关性。游离 T 和游离及总 E2 与所有 QUS 读数均呈正相关，而 SHBG 浓度则呈负相关。这些关系在年龄较大（≥60 岁）和较小（<60 岁）的男性中均存在。在多变量模型中，在调整年龄、中心、身高、体重、体力活动水平和吸烟因素后，游离 E2 和 SHBG 与 QUS 参数仍独立相关，而游离 T 则无相关性。然而，进一步调整 IGF-1 后，SHBG 与 QUS 参数的相关性不再显著。
游离和总 E2 水平较高与骨骼健康相关，不仅在老年人群中如此，在中年欧洲男性中也是如此。
