Respiratory Diseases Section, Department of Clinical Medicine and Immunology, Siena University, Siena, Italy.
Rheumatol Int. 2011 Nov;31(11):1503-6. doi: 10.1007/s00296-009-1315-7. Epub 2009 Dec 15.
Sarcoidosis is a multisystem disease of unknown origin. Granulomatous bone involvement has an overall incidence of 1-13%. This incidence is probably underestimated in certain patient series because bone involvement is often asymptomatic. The small bones of hands and feet are the most common localizations, while skull, knee, rib, pelvic and sternal localizations are rarely reported. Here we describe some interesting cases of chronic sarcoidosis with unusual bone localizations observed at our regional referral centre for sarcoidosis. We also review the literature to underline the complexity of the disease, the problem of differential diagnosis with respect to malignancies and the need for appropriate and effective therapy of this rare localization.
结节病是一种病因不明的多系统疾病。肉芽肿性骨受累的总体发生率为 1-13%。由于骨受累通常无症状，因此在某些患者系列中，这一发生率可能被低估。手和脚的小骨头是最常见的部位，而颅骨、膝盖、肋骨、骨盆和胸骨部位则很少见。在这里，我们描述了在我们的结节病区域转诊中心观察到的一些具有不常见骨部位的慢性结节病的有趣病例。我们还回顾了文献，强调了该疾病的复杂性、与恶性肿瘤鉴别的问题以及对这种罕见部位进行适当和有效治疗的必要性。
