Department of Ophthalmology, Qilu Hospital of Shandong University, Jinan, China.
PLoS One. 2012;7(8):e43500. doi: 10.1371/journal.pone.0043500. Epub 2012 Aug 27.
To study the long-term effects of low-dosage strontium-90 (Sr90) irradiation on the recurrence of pterygium.
METHODOLOGY/PRINCIPAL FINDINGS: One hundred twenty eyes from 104 patients with primary or recurrent pterygia were treated with surgery followed by Sr90 irradiation. In brief, starting on the sixth day after surgery, patients were treated with irradiation three times every other day at a total combined dosage of 2000 cGy to 3000 cGy. Corneal topography was used to evaluate ocular surface regularity before and after treatment. Patient follow-up was performed 2 days, 5 days, 2 weeks, 1 month, 3 months, 1 year, 5 years, and 10 years after surgery. Recurrence of pterygium was not observed in any of the patients in this study. Obvious cataract progression was observed in 6 eyes, which may be due to aging. During follow-up studies, only one eye was reported with dryness and foreign-body sensation. Significant pterygium-induced astigmatism was observed in corneal topography, which decreased after surgery.
CONCLUSIONS/SIGNIFICANCE: Sr90 irradiation is effective in preventing the recurrence of primary and recurrent pterygia. We recommend delivering a total combined dosage of 2000 cGy to 3000 cGy of Sr90 irradiation administered in three batches every other day starting from the sixth day after surgery. Surgery is important in the rapid recovery of the cornea from pterygium-induced astigmatism.
研究低剂量锶-90（Sr90）照射对翼状胬肉复发的长期影响。
方法/主要发现：104 例原发性或复发性翼状胬肉患者的 120 只眼接受了手术联合 Sr90 照射治疗。简要来说，术后第 6 天开始，患者每隔一天接受 3 次照射，总剂量为 2000cGy 至 3000cGy。治疗前后采用角膜地形图评估眼表规则性。术后 2 天、5 天、2 周、1 个月、3 个月、1 年、5 年和 10 年对患者进行随访。本研究中未观察到任何患者的翼状胬肉复发。6 只眼观察到明显的白内障进展，可能与年龄有关。在随访研究中，仅 1 只眼报告有干燥和异物感。角膜地形图显示翼状胬肉引起的散光明显，术后散光减轻。
结论/意义：Sr90 照射可有效预防原发性和复发性翼状胬肉的复发。我们建议在术后第 6 天开始，每隔一天分 3 次给予 2000cGy 至 3000cGy 的 Sr90 照射总剂量。手术对于翼状胬肉引起的散光快速恢复角膜非常重要。
