School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, I.R. Iran.
Phytother Res. 2010 Jul;24(7):990-4. doi: 10.1002/ptr.3044.
In this study, the effects of saffron (Crocus sativus) stigma aqueous extract and two active constituents, crocin and safranal, were investigated on blood pressure of normotensive and desoxycorticosterone acetate-induced hypertensive rats. Three doses of crocin (50, 100 and 200 mg/kg), safranal (0.25, 0.5 and 1 mg/kg) and the aqueous extract (2.5, 5 and 10 mg/kg) were administered intravenously in different groups of normotensive and hypertensive animals and their effects on mean arterial blood pressure (MABP) and heart rate (HR) were evaluated. The aqueous extract of saffron stigma, safranal and crocin reduced the MABP in normotensive and hypertensive anaesthetized rats in a dose-dependent manner. For example, administrations of 10 mg/kg of aqueous extract, 1 mg/kg of safranal and 200 mg/kg of crocin caused 60 +/- 8.7, 50 +/- 5.2 and 51 +/- 3.8 mmHg reductions in MABP, respectively. It can be concluded that the aqueous extract of saffron stigma has hypotensive properties which appear to be attributable, in part, to the actions of two major constitutes of this plant, crocin and safranal. It seems that safranal is more important than crocin for lowering down blood pressure of rats.
在这项研究中，研究了藏红花（Crocus sativus）柱头水提取物以及两种活性成分藏红花酸和西红花醛对正常血压和去氧皮质酮乙酸盐诱导的高血压大鼠血压的影响。以静脉注射方式给不同剂量的藏红花酸（50、100 和 200mg/kg）、西红花醛（0.25、0.5 和 1mg/kg）和水提取物（2.5、5 和 10mg/kg），评估它们对平均动脉血压（MABP）和心率（HR）的影响。藏红花柱头水提取物、西红花醛和藏红花酸以剂量依赖的方式降低正常血压和麻醉高血压大鼠的 MABP。例如，静脉注射 10mg/kg 的水提取物、1mg/kg 的西红花醛和 200mg/kg 的藏红花酸，分别使 MABP降低 60+/-8.7、50+/-5.2 和 51+/-3.8mmHg。可以得出结论，藏红花柱头水提取物具有降血压特性，这部分归因于该植物的两种主要成分，藏红花酸和西红花醛。西红花醛似乎比藏红花酸更能降低大鼠的血压。
