Division of Rheumatology, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA.
Autoimmunity. 2010 Feb;43(1):84-97. doi: 10.3109/08916930903374600.
It has long been known that B cells produce autoantibodies and, thereby, contribute to the pathogenesis of many autoimmune diseases. Systemic lupus erythematosus (SLE), a prototypic systemic autoimmune disorder, is characterized by high-circulating autoantibody titers and immune-complex deposition that can trigger inflammatory damage in multiple organs/organ systems. Although the interest in B cells in SLE has historically focused on their autoantibody production, we now appreciate that B cells have multiple autoantibody-independent roles in SLE as well. B cells can efficiently present antigen and activate T cells, they can augment T cell activation through co-stimulatory interactions, and they can produce numerous cytokines which affect inflammation, lymphogenesis, and immune regulation. Not surprisingly, B cells have become attractive therapeutic targets in SLE. With these points in mind, this review will focus on the autoantibody-dependent and autoantibody-independent roles for B cells in SLE and on therapeutic approaches that target B cells.
长期以来，人们一直知道 B 细胞会产生自身抗体，从而导致许多自身免疫性疾病的发病机制。系统性红斑狼疮（SLE）是一种典型的全身性自身免疫性疾病，其特征是循环中自身抗体滴度高和免疫复合物沉积，从而在多个器官/器官系统中引发炎症损伤。尽管人们对 SLE 中 B 细胞的兴趣历来集中在其产生自身抗体上，但我们现在认识到，B 细胞在 SLE 中也具有多种与自身抗体无关的作用。B 细胞可以有效地呈递抗原并激活 T 细胞，它们可以通过共刺激相互作用增强 T 细胞的激活，并且它们可以产生多种影响炎症、淋巴发生和免疫调节的细胞因子。毫不奇怪，B 细胞已成为 SLE 的有吸引力的治疗靶点。考虑到这些要点，本综述将重点介绍 B 细胞在 SLE 中的自身抗体依赖性和自身抗体非依赖性作用，以及针对 B 细胞的治疗方法。
