Shen Liang, Que Hua-fa
Department of Traditional Chinese Surgery, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China.
Zhong Xi Yi Jie He Xue Bao. 2009 Dec;7(12):1150-3. doi: 10.3736/jcim20091211.
To investigate the efficacy of oral, external and oral plus external application of recipes for promoting granulation on chronic skin ulcers in rats.
Sixty SD male rats were randomly divided into normal group, untreated group, oral group, external group and combined group (n=12). Chronic skin ulcer was induced by hydrocortisone injection and back skin incision. After oral administration of Fuzheng Huyu Recipe or (and) external application of Baiyu ointment, the compound traditional Chinese medicines for wound healing, healing time and healing rate of the ulcers were observed.
The healing rate was lower and the healing time was longer in the untreated group than in the normal group (P<0.01). The healing rates of the oral group and the combined group were higher than those of the untreated group at all observation points (P<0.05), and the healing rate of the external group was higher on the 3rd and 14th day after model establishment (P<0.05). On the 7th and 10th day after model establishment, the healing rates of the oral group and the combined group were higher than those of the external group (P<0.05), and the healing time of the combined group was shorter than that of the oral group and external group (P<0.05).
Both orally and externally administered wound healing recipes can promote the restoration of chronic refractory ulcers; the effect of combined administration is superior to single administration. Oral, external and combined application can all improve the wound healing in inflammatory phase. Oral and combined application can obviously improve the wound healing in granulation phase and epithelial phase.
探讨促进肉芽生长方剂口服、外用及口服加外用对大鼠慢性皮肤溃疡的疗效。
将60只雄性SD大鼠随机分为正常组、未治疗组、口服组、外用组和联合组（n = 12）。通过注射氢化可的松并在背部皮肤切开诱导慢性皮肤溃疡。给予扶正化瘀方口服或（和）外用白玉膏后，观察溃疡的愈合时间、愈合率及复方中药促进伤口愈合的情况。
未治疗组的愈合率低于正常组，愈合时间长于正常组（P<0.01）。在各观察点，口服组和联合组的愈合率均高于未治疗组（P<0.05），外用组在造模后第3天和第14天的愈合率较高（P<0.05）。在造模后第7天和第10天，口服组和联合组的愈合率高于外用组（P<0.05），联合组的愈合时间短于口服组和外用组（P<0.05）。
促进伤口愈合的方剂口服和外用均能促进慢性难治性溃疡的修复；联合给药效果优于单一给药。口服、外用及联合应用均可改善炎症期伤口愈合。口服及联合应用可明显改善肉芽组织期和上皮期伤口愈合。
