Department of Medical Oncology, National Cancer Institute, Cairo University, 55 Abdel Monem Riad Street, Mohandeseen, Cairo, Egypt.
Cancer Treat Rev. 2010 Apr;36(2):101-9. doi: 10.1016/j.ctrv.2009.11.007. Epub 2009 Dec 16.
The association of cancer and pregnancy is increasingly encountered nowadays in clinical practice. Due to the relative rarity of the situation, it lacks a systematized approach. Different systemic therapies are used in managing cancer with uncertainty regarding the potential hazards they could pose on the pregnancy and/or the fetus. We have performed a systematic review of literature to identify all reports addressing cancer patients who were exposed to any of the known systemic therapies during the course of the pregnancy. The results were discussed in two parts; part I addresses pregnant patients with solid tumors while part I for those with hematological malignancies. In part I, we identified different solid tumors diagnosed and treated during the course of pregnancy. Breast cancer was the most commonly treated followed by ovarian cancer. Other tumors were treated as well including lung cancer, cervical cancer, sarcoma and melanomas. It is important to acknowledge the intent of therapy (palliative vs. curative) and the patients has to be properly counseled to reach an informed decision. We aim to provide a more robust consensus on how to approach these cases and provide a higher degree of evidence to support the safety of applying certain management strategies over the other.
如今，癌症与妊娠的关联在临床实践中越来越常见。由于这种情况相对罕见，因此缺乏系统的处理方法。在治疗癌症时会使用不同的系统疗法，但不确定这些疗法会对妊娠和/或胎儿造成哪些潜在危害。我们对文献进行了系统回顾，以确定所有涉及在妊娠期间暴露于任何已知系统疗法的癌症患者的报告。结果分为两部分讨论；第一部分针对患有实体瘤的孕妇，第二部分针对患有血液系统恶性肿瘤的孕妇。在第一部分中，我们确定了在妊娠期间诊断和治疗的不同实体瘤。乳腺癌是最常见的治疗方法，其次是卵巢癌。其他肿瘤也得到了治疗，包括肺癌、宫颈癌、肉瘤和黑色素瘤。重要的是要了解治疗的目的（姑息性与根治性），并对患者进行适当的咨询，以做出知情决策。我们的目标是就如何处理这些病例提供更有力的共识，并提供更高程度的证据来支持应用某些管理策略的安全性，而不是其他策略。
