甲状腺结节和甲状腺癌患者的维生素 D 缺乏患病率相似。
The Prevalence of Vitamin D Deficiency Is Similar between Thyroid Nodule and Thyroid Cancer Patients.
机构信息
Department of Internal Medicine, Section of Diabetes, Endocrinology, and Metabolism, University of Nebraska Medical Center, Omaha, NE 68198-3020, USA.
出版信息
Int J Endocrinol. 2010;2010:805716. doi: 10.1155/2010/805716. Epub 2009 Sep 6.
Introduction. There are reported associations between vitamin D deficiency and breast, prostate, and colon cancer, but the relationship in thyroid cancer has not been evaluated. Methods. We evaluated serum calcium, creatinine, albumin, and 25-hydroxy vitamin D (25-OH-D) in 42 thyroid nodule, 45 thyroid cancer in remission, and 24 active thyroid cancer patients. Results. 25-OH-D was not different between groups. The percent with 25-OH-D levels <75 nmol/L was not significantly different between groups and was not affected by season of measurement, age, or cancer stage. Multivariate regression showed a BMI of >/=30 kg/m(2) to be the only significant predictor of vitamin D deficiency. Conclusions. Rates of vitamin D deficiency are similar in thyroid nodules and thyroid cancer, although higher than the general population. This is different than previous studies for other cancers, which show higher rates of vitamin D deficiency. BMI was the only predictor of vitamin D deficiency.
简介。据报道，维生素 D 缺乏与乳腺癌、前列腺癌和结肠癌之间存在关联，但尚未评估其与甲状腺癌的关系。方法。我们评估了 42 例甲状腺结节、45 例甲状腺癌缓解期和 24 例活动性甲状腺癌患者的血清钙、肌酐、白蛋白和 25-羟维生素 D（25-OH-D）水平。结果。25-OH-D 在各组之间无差异。25-OH-D 水平<75 nmol/L 的百分比在各组之间无显著差异，且不受测量季节、年龄或癌症分期的影响。多变量回归显示 BMI≥30 kg/m2 是维生素 D 缺乏的唯一显著预测因素。结论。甲状腺结节和甲状腺癌中维生素 D 缺乏的发生率相似，尽管高于一般人群。这与其他癌症的先前研究不同，后者显示出更高的维生素 D 缺乏率。BMI 是维生素 D 缺乏的唯一预测因素。
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