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CLA（共轭亚油酸）异构体的特异性：9E,11E-CLA。

Isomer specificity of conjugated linoleic acid (CLA): 9E,11E-CLA.

机构信息

Obesity and metabolism laboratory, Jean Mayer USDA HNRCA at Tufts University, Boston, MA 02111, USA.

出版信息

Nutr Res Pract. 2008 Winter;2(4):326-30. doi: 10.4162/nrp.2008.2.4.326. Epub 2008 Dec 31.

DOI:10.4162/nrp.2008.2.4.326
PMID:20016738
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2788195/
Abstract

Conjugated linoleic acids (CLA) were identified in 1980's, since then it has been intensively studied due to its various beneficial health effects such as anti-inflammatory, anti-atherogenic, anti-carcinogenic and anti-diabetic/obesity effects. Isomer specificity of a number of CLA isomers, especially predominant isomer 9Z,11E- and 10E,12Z-CLA, is now recognized. However, the less prevalent CLA isomers have not been well characterized. Recently, studies have reported the distinctively different effects of 9E,11E-CLA in colon cancer cells, endothelial cells, and macrophage cells compared to the rest of CLA isomers. In this review, various effects of CLAs, especially anti-inflammatory and anti-atherogenic effects, will be discussed with focusing on the isomer-specific effects and potential mechanism of action of CLA. At last, recent studies about 9E,11E-CLA in in vitro and animal models will be discussed.

摘要

共轭亚油酸（CLA）于 20 世纪 80 年代被发现，由于其具有多种有益的健康作用，如抗炎、抗动脉粥样硬化、抗癌和抗糖尿病/肥胖作用，此后一直受到广泛研究。目前已经确定了多种 CLA 异构体的异构体特异性，特别是主要的异构体 9Z,11E-和 10E,12Z-CLA。然而，较少见的 CLA 异构体尚未得到很好的表征。最近的研究报告称，与其他 CLA 异构体相比，9E,11E-CLA 在结肠癌细胞、内皮细胞和巨噬细胞中的作用明显不同。在这篇综述中，将讨论 CLA 的各种作用，特别是抗炎和抗动脉粥样硬化作用，并重点讨论 CLA 的异构体特异性作用和潜在作用机制。最后，将讨论最近关于 9E,11E-CLA 的体外和动物模型研究。

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本文引用的文献

1
Isomer-specific effects of conjugated linoleic acid on gene expression in RAW 264.7.
J Nutr Biochem. 2009 Nov;20(11):848-59, 859.e1-5. doi: 10.1016/j.jnutbio.2008.07.013. Epub 2008 Nov 6.
2
9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats.
Nutr Cancer. 2007;59(1):82-91. doi: 10.1080/01635580701419055.
3
Isomer specific effects of Conjugated Linoleic Acid on macrophage ABCG1 transcription by a SREBP-1c dependent mechanism.
Biochem Biophys Res Commun. 2007 Jan 19;352(3):805-11. doi: 10.1016/j.bbrc.2006.11.087. Epub 2006 Nov 27.
4
Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice.
J Nutr Biochem. 2007 Jul;18(7):467-74. doi: 10.1016/j.jnutbio.2006.08.002. Epub 2006 Sep 25.
5
Cytokine-induced monocyte adhesion to endothelial cells involves platelet-activating factor: suppression by conjugated linoleic acid.
Biochim Biophys Acta. 2006 Jul;1761(7):793-801. doi: 10.1016/j.bbalip.2006.05.014. Epub 2006 Jun 2.
6
Biological effects of conjugated linoleic acids in health and disease.
J Nutr Biochem. 2006 Dec;17(12):789-810. doi: 10.1016/j.jnutbio.2006.02.009. Epub 2006 May 2.
7
Potent inhibitory effect of trans9, trans11 isomer of conjugated linoleic acid on the growth of human colon cancer cells.
J Nutr Biochem. 2006 Dec;17(12):830-6. doi: 10.1016/j.jnutbio.2006.01.007. Epub 2006 Mar 24.
8
Conjugated linoleic acid isomers reduce blood cholesterol levels but not aortic cholesterol accumulation in hypercholesterolemic hamsters.
Lipids. 2006 Jan;41(1):41-8. doi: 10.1007/s11745-006-5068-8.
9
Selective effect of conjugated linoleic acid isomers on atherosclerotic lesion development in apolipoprotein E knockout mice.
Atherosclerosis. 2006 Dec;189(2):318-27. doi: 10.1016/j.atherosclerosis.2006.01.015. Epub 2006 Mar 13.
10
The cis-9,trans-11 isomer of conjugated linoleic acid (CLA) lowers plasma triglyceride and raises HDL cholesterol concentrations but does not suppress aortic atherosclerosis in diabetic apoE-deficient mice.
Atherosclerosis. 2006 Dec;189(2):282-7. doi: 10.1016/j.atherosclerosis.2005.12.020. Epub 2006 Feb 13.

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