Institute of Preventive Medicine, Center for Health and Society, Copenhagen University Hospital, Copenhagen, Denmark.
PLoS One. 2009 Dec 16;4(12):e8192. doi: 10.1371/journal.pone.0008192.
Prenatal life exposures, potentially manifested as altered birth size, may influence the later risk of major chronic diseases through direct biologic effects on disease processes, but also by modifying adult behaviors such as physical activity that may influence later disease risk.
METHODS/PRINCIPAL FINDINGS: We investigated the association between birth weight and leisure time physical activity (LTPA) in 43,482 adolescents and adults from 13 Nordic cohorts. Random effects meta-analyses were performed on categorical estimates from cohort-, age-, sex- and birth weight specific analyses. Birth weight showed a reverse U-shaped association with later LTPA; within the range of normal weight the association was negligible but weights below and above this range were associated with a lower probability of undertaking LTPA. Compared with the reference category (3.26-3.75 kg), the birth weight categories of 1.26-1.75, 1.76-2.25, 2.26-2.75, and 4.76-5.25 kg, had odds ratios of 0.67 (95% confidence interval: 0.47, 0.94), 0.72 (0.59, 0.88), 0.89 (0.79, 0.99), and 0.65 (0.50, 0.86), respectively. The shape and strength of the birth weight-LTPA association was virtually independent of sex, age, gestational age, educational level, concurrent body mass index, and smoking.
CONCLUSIONS/SIGNIFICANCE: The association between birth weight and undertaking LTPA is very weak within the normal birth weight range, but both low and high birth weights are associated with a lower probability of undertaking LTPA, which hence may be a mediator between prenatal influences and later disease risk.
产前生活暴露，可能表现为出生体重改变，可能通过对疾病过程的直接生物学效应，以及通过改变可能影响以后疾病风险的成人行为（如体力活动），来影响以后发生重大慢性疾病的风险。
方法/主要发现：我们调查了来自 13 个北欧队列的 43482 名青少年和成年人的出生体重与休闲时间体力活动（LTPA）之间的关系。对基于队列、年龄、性别和出生体重特定分析的分类估计值进行了随机效应荟萃分析。出生体重与以后的 LTPA 呈反向 U 型关联；在正常体重范围内，关联可以忽略不计，但体重低于或高于该范围与进行 LTPA 的可能性较低相关。与参考类别（3.26-3.75kg）相比，1.26-1.75kg、1.76-2.25kg、2.26-2.75kg 和 4.76-5.25kg 的出生体重类别具有 0.67（95%置信区间：0.47，0.94）、0.72（0.59，0.88）、0.89（0.79，0.99）和 0.65（0.50，0.86）的比值比。出生体重与 LTPA 之间的关联的形状和强度在正常出生体重范围内非常弱，但低出生体重和高出生体重均与进行 LTPA 的可能性降低相关，这可能是产前影响与以后疾病风险之间的一个中介因素。
