Weatherton Linda K, Streeter Elizabeth M
From the Eastern Iowa Veterinary Specialty Center, Department of Emergency and Critical Care, Cedar Rapids, IA 52404, USA.
J Vet Emerg Crit Care (San Antonio). 2009 Dec;19(6):617-22. doi: 10.1111/j.1476-4431.2009.00483.x.
Compare outcome of dogs that did and did not receive fresh frozen plasma (FFP) for treatment of pancreatitis.
Retrospective case series between 1995 and 2005.
University referral hospital.
Seventy-four dogs were enrolled with a total of 77 cases as 2 dogs had repeat episodes of pancreatitis. Diagnosis of pancreatitis was based on clinical signs, physical examination, and abdominal ultrasonographic examination.
The medical database was searched for dogs with a diagnosis of pancreatitis. Information collected included signalment, vital signs, CBC, use of FFP, length of stay, use of antimicrobials and supplemental nutrition, surgical intervention, preexisting illness, evidence of a coagulopathy and outcome. Outcome was compared between those patients that did and did not receive FFP.
Fifty-nine dogs survived to discharge. Two dogs with repeat pancreatitis survived to discharge after each episode. Thirteen dogs died and 2 were euthanized. FFP was administered to 20 dogs. Two dogs that were hospitalized for repeat pancreatitis did not receive FFP. Seven of 20 (35%) cases that received plasma died or were euthanized compared with 6 of 57 (12%) cases that did not receive plasma. Plasma administration was significantly related to outcome (P<0.001). Severity of illness scores were difficult to assign, however, dogs meeting criteria for systemic inflammatory response syndrome were not more likely to receive FFP. Other therapies included supplemental nutrition, antimicrobials, and surgical intervention, which did not affect outcome.
Mortality rate for those dogs receiving plasma was higher than those that did not. Severity of illness scores were difficult to assign; however, preexisting illness, evidence of systemic inflammatory response syndrome, and presence of a coagulopathy were not significantly different between the groups that did and did not receive FFP. No benefit for administration of FFP was noted. Additional investigation should be performed to confirm this result.
比较接受和未接受新鲜冰冻血浆(FFP)治疗胰腺炎的犬只的治疗结果。
1995年至2005年的回顾性病例系列研究。
大学转诊医院。
纳入74只犬,共77例病例,其中2只犬有胰腺炎复发情况。胰腺炎的诊断基于临床症状、体格检查和腹部超声检查。
在医学数据库中搜索诊断为胰腺炎的犬只。收集的信息包括特征、生命体征、全血细胞计数、FFP的使用情况、住院时间、抗菌药物和补充营养的使用情况、手术干预、既往疾病、凝血功能障碍证据及治疗结果。比较接受和未接受FFP的患者的治疗结果。
59只犬存活出院。2只胰腺炎复发的犬每次发作后均存活出院。13只犬死亡,2只被安乐死。20只犬接受了FFP治疗。2只因胰腺炎复发住院的犬未接受FFP治疗。接受血浆治疗的20例病例中有7例(35%)死亡或被安乐死,而未接受血浆治疗的57例病例中有6例(12%)死亡或被安乐死。血浆治疗与治疗结果显著相关(P<0.001)。疾病严重程度评分难以确定,然而,符合全身炎症反应综合征标准的犬只接受FFP的可能性并不更高。其他治疗包括补充营养、抗菌药物和手术干预,这些均未影响治疗结果。
接受血浆治疗的犬只死亡率高于未接受血浆治疗的犬只。疾病严重程度评分难以确定;然而,接受和未接受FFP的两组之间,既往疾病、全身炎症反应综合征证据和凝血功能障碍的存在情况并无显著差异。未发现FFP治疗有任何益处。应进行进一步研究以证实该结果。