Liu Xiao-Wan, Zhang Yao-Hui, Xu Li, Xing Jia-Bao, Wang Zhou-Xiang, Hu Man-Li, Chen Yun, Qi Zhi-Li, Ding Yi, Zhang Xin, Ding Ming-Xing, Zhang Xiao-Jing, Wan Juan
Gannan Innovation and Translational Medicine Research Institute, First Affiliated Hospital, Gannan Medical University, Ganzhou, China.
School of Public Health and Health Management, Gannan Medical University, Ganzhou, China.
PLoS One. 2025 Feb 13;20(2):e0318159. doi: 10.1371/journal.pone.0318159. eCollection 2025.
To investigate the role of quercetin-added pancreatic prescription food in regulating metabolic homeostasis in dogs.
The experimental dogs were divided into a control diet group and a prescription diet group. The control group was fed regular food, while the prescription group was fed pancreatic prescription food (3.9 g of quercetin was added in per 1 kg of food) for 8 weeks. Canine physical examination, complete blood count, and serum biochemical tests were conducted at 0 w, 4 w, and 8 w. Non-targeted metabolomics tests were performed using plasma samples at 0 w and 8 w.
Dogs that received a quercetin-added pancreatic diet supplemented with quercetin showed no changes in the body weight, fasting blood glucose, body condition score, the indexes of whole blood program of red blood cells, white blood cells and platelets, and most blood biochemical indexes, but increased lipase levels in plasma at 8 w. Quercetin significant improved in metabolic homeostasis, especially in fatty acid, amino acid, and bile acid metabolism. Untargeted metabolomics analysis revealed that quercetin activates ABC transport and arginine/proline pathways, suggesting potential benefits for pancreatitis in large animals, while maintaining comparable safety parameters.
Quercetin-added prescription food enhances fatty acid and amino acid metabolism, demonstrating its potential to promote pancreatic function and sustain metabolic homeostasis.
研究添加槲皮素的胰腺处方食品在调节犬类代谢稳态中的作用。
将实验犬分为对照饮食组和处方饮食组。对照组喂食常规食物，而处方组喂食胰腺处方食品（每1千克食物中添加3.9克槲皮素），持续8周。在第0周、第4周和第8周进行犬类体格检查、全血细胞计数和血清生化检测。在第0周和第8周使用血浆样本进行非靶向代谢组学检测。
接受添加槲皮素的胰腺饮食的犬只在体重、空腹血糖、身体状况评分、红细胞、白细胞和血小板全血程序指标以及大多数血液生化指标方面没有变化，但在第8周时血浆中脂肪酶水平升高。槲皮素显著改善了代谢稳态，尤其是在脂肪酸、氨基酸和胆汁酸代谢方面。非靶向代谢组学分析表明，槲皮素激活了ABC转运和精氨酸/脯氨酸途径，这表明对大型动物胰腺炎有潜在益处，同时保持了相当的安全参数。
添加槲皮素的处方食品增强了脂肪酸和氨基酸代谢，证明了其促进胰腺功能和维持代谢稳态的潜力。
