Janoff E N, Orenstein J M, Manischewitz J F, Smith P D
Department of Medicine, Veterans Affairs Medical Center, University of Minnesota School of Medicine, Minneapolis.
Gastroenterology. 1991 Apr;100(4):976-9. doi: 10.1016/0016-5085(91)90272-m.
Adenovirus was identified in colonic tissue by transmission electron microscopy or culture in 5 of 67 (7.4%) homosexual men seropositive for human immunodeficiency virus (51 with the acquired immunodeficiency syndrome) with diarrhea. Colonoscopy showed the mucosa to be normal in 3 cases and mildly inflamed in 2. Light microscopy showed foci of mucosal necrosis that contained chronic inflammatory cells and degenerating and necrotic epithelial cells with amphophilic nuclear inclusions. By transmission electron microscopy, hexagonal viral particles characteristic of adenovirus were identified within the inclusions. Only 1 patient was concomitantly infected by a second potential enteric pathogen. It was concluded that adenovirus, an uncommon enteric pathogen in immunocompetent adults, causes intestinal pathology and may be associated with diarrheal illness in persons with the acquired immunodeficiency syndrome.
通过透射电子显微镜或培养在67名感染人类免疫缺陷病毒血清阳性（51例患有获得性免疫缺陷综合征）且腹泻的同性恋男性中的5例（7.4%）结肠组织中鉴定出腺病毒。结肠镜检查显示3例黏膜正常，2例轻度炎症。光镜检查显示黏膜坏死灶，其中含有慢性炎症细胞以及变性和坏死的上皮细胞，并伴有嗜两性核内包涵体。通过透射电子显微镜，在包涵体内鉴定出具有腺病毒特征的六边形病毒颗粒。仅1例患者同时感染了另一种潜在的肠道病原体。结论是，腺病毒在免疫功能正常的成年人中是一种不常见的肠道病原体，可导致肠道病变，并且可能与获得性免疫缺陷综合征患者的腹泻病有关。
