Rene E, Marche C, Chevalier T, Rouzioux C, Regnier B, Saimot A G, Negesse Y, Matheron S, Leport C, Wolff B
Department of Gastroenterology, Hôpital Bichat, Paris, France.
Dig Dis Sci. 1988 Jun;33(6):741-50. doi: 10.1007/BF01540440.
Twenty-four AIDS patients, who underwent gastrointestinal evaluation, died from their disease and were autopsied. Seven had Cytomegalovirus colitis (group I) and 17 did not (group II). Clinical manifestations, digestive lesions, and infections were compared in the two groups. Chronic watery diarrhea was present in all the patients with colitis but was also present in 65% of the patients without colitis. Hematochezia was present only in the group with colitis (one of seven patients) but appeared late in the diarrheal course, due to necrotizing colitis. No other difference were noted between the two groups (mean duration of diarrhea, frequency and nature of the other infections). As for group I specifically, colonic ulcerations due to Cytomegalovirus were present in all the patients, varying from punctate and superficial erosions to deep ulcerations, with granular and friable intervening mucosa. Severe colonic lesions appeared during the course of Cytomegalovirus colitis in two patients who developed lethal necrotizing colitis. Finally, the clinical and pathologic features of these seven cases were compared to other reports of Cytomegalovirus infection of the colon.
24例接受过胃肠道评估的艾滋病患者因病死亡并接受了尸检。其中7例患有巨细胞病毒性结肠炎（I组），17例未患（II组）。对两组患者的临床表现、消化系统病变及感染情况进行了比较。所有患有结肠炎的患者均有慢性水样腹泻，但65%未患结肠炎的患者也有此症状。便血仅出现在患有结肠炎的组中（7例患者中的1例），但由于坏死性结肠炎，在腹泻病程后期出现。两组之间未发现其他差异（腹泻平均持续时间、其他感染的频率及性质）。具体到I组，所有患者均存在由巨细胞病毒引起的结肠溃疡，从点状和浅表糜烂到深部溃疡不等，其间黏膜呈颗粒状且质脆。两名发展为致死性坏死性结肠炎的患者在巨细胞病毒性结肠炎病程中出现了严重的结肠病变。最后，将这7例病例的临床和病理特征与其他关于结肠巨细胞病毒感染的报告进行了比较。
