类风湿关节炎中携带B27的HLA单倍型：芬兰患者的特征分析

B27-bearing HLA haplotypes in rheumatoid arthritis: characterization in Finnish patients.

作者信息

Ilonen J, Hakala M, Reijonen H, Tiilikainen A

机构信息

Department of Medical Microbiology, University of Oulu, Finland.

出版信息

Hum Immunol. 1991 Jan;30(1):7-10. doi: 10.1016/0198-8859(91)90063-f.

DOI:10.1016/0198-8859(91)90063-f

PMID:2001978

Abstract

The frequency of human leukocyte antigen (HLA)-B27 has been found to be increased in rheumatoid arthritis (RA) in Finland and marginally also in some other populations. In the present study HLA-B27-bearing haplotypes in RA patients were found to carry DR1 and DR4 genes more often than do B27 haplotypes in control population. B27;DR4,DW14;DQw7 was a typical B27-DR4 haplotype whereas DR4 in the majority of other haplotypes occurs with Dw4 and DQw8 genes. The result indicates that the B27 association with RA is not independent of DR1 and DR4, but whether the B27;DR4;DQw7 haplotype subjects a person to a higher disease risk than do other DR4 haplotypes, or is associated with a more severe course of the disease, remains to be investigated.

摘要

研究发现，在芬兰类风湿关节炎（RA）患者中，人类白细胞抗原（HLA）-B27的频率有所增加，在其他一些人群中也略有增加。在本研究中，发现RA患者中携带HLA-B27的单倍型比对照人群的B27单倍型更常携带DR1和DR4基因。B27;DR4,DW14;DQw7是典型的B27-DR4单倍型，而在大多数其他单倍型中，DR4与Dw4和DQw8基因同时出现。结果表明，B27与RA的关联并非独立于DR1和DR4，但是B27;DR4;DQw7单倍型是否会使个体比其他DR4单倍型面临更高的疾病风险，或者是否与更严重的病程相关，仍有待研究。