家族性和散发性类风湿关节炎中的人类白细胞抗原DR4和B27抗原

HLA DR4 and B27 antigens in familial and sporadic rheumatoid arthritis.

作者信息

Khan M A, Wolfe F, Kleinheksel S M, Molta C

机构信息

Case Western Reserve University, Cleveland Metropolitan General Hospital, Ohio.

出版信息

Scand J Rheumatol. 1987;16(6):433-6. doi: 10.3109/03009748709165415.

DOI:10.3109/03009748709165415

PMID:3501160

Abstract

We studied HLA antigens in 105 unrelated American Caucasian patients with rheumatoid arthritis (RA), 70 of them with familial disease. HLA-DR4 was observed in 71% of familial RA, 63% of non-familial RA, and 27% of normal controls, confirming the already well-established association between HLA-DR4 and both familial and non-familial RA. HLA-B27 was present in 14.3% of patients, versus 8% of normal controls (p = 0.04), and was not more common in familial (10 of 70, or 14.3%) versus non-familial (5 of 35, or 14.3%) disease. These results are compared with those observed in Scandinavian patients.

摘要

我们研究了105名无亲缘关系的美国白种类风湿关节炎（RA）患者的HLA抗原，其中70名有家族病史。在71%的家族性RA患者、63%的非家族性RA患者和27%的正常对照中观察到HLA - DR4，证实了HLA - DR4与家族性和非家族性RA之间已确立的关联。14.3%的患者存在HLA - B27，而正常对照中这一比例为8%（p = 0.04），在家族性疾病（70例中的10例，即14.3%）和非家族性疾病（35例中的5例，即14.3%）中，HLA - B27的出现频率并无差异。将这些结果与在斯堪的纳维亚患者中观察到的结果进行了比较。