Zhang An-yang, Fan Tian-yuan
Department of Pharmaceutics, Peking University School of Pharmaceutical Sciences, Beijing 100191, China.
Beijing Da Xue Xue Bao Yi Xue Ban. 2009 Dec 18;41(6):682-6.
To investigate the preparation, optimization and in vitro properties of riboflavin sodium phosphate floating microspheres.
The floating microspheres composed of riboflavin sodium phosphate and calcium alginate were prepared using ion gelatin-oven drying method.
The properties of the microspheres were investigated, including the buoyancy, release, appearance and entrapment efficiency. The formulation was optimized by response surface methodology (RSM).
The optimized microspheres were round. The entrapment efficiency was 57.49%. All the microspheres could float on the artificial gastric juice over 8 hours. The release of the drug from the microspheres complied with Fick's diffusion.
考察核黄素磷酸钠胃内漂浮微球的制备、优化及其体外性质。
采用离子交联-烘箱干燥法制备核黄素磷酸钠-海藻酸钙胃内漂浮微球。
考察了微球的漂浮性、释放度、外观及包封率等性质，并采用响应面法（RSM）对处方进行优化。
优化后的微球呈圆形，包封率为57.49%。所有微球在人工胃液中均能漂浮8小时以上，药物从微球中的释放符合Fick扩散规律。
