Jiang Hui-ming, Zhang Liang-ke, Yuan Pei, Wang Cheng-yuan, Long You-qi
School of Pharmacy, Chongqing 400016, China.
Zhong Yao Cai. 2011 Feb;34(2):281-4.
To prepare calcium alginate-chitosan intra-gastric floating beads of naringenin combining with the solid dispersion method and investigate the in vitro floating characteristics, entrapment efficiency and drug release property of the beads.
The solid dispersion of naringenin was prepared by the Eudragit RLPO. Sodium alginate solution mixed with the powder of the solid dispersion of naringenin and frother was slowly dripped into chitosan-calcium chloride solution added with acetic acid. Calcium alginatechitosan intra-gastric floating beads of naringenin were obtained after drying. The effects of solid dispersion on in vitro release of naringenin were investigated.
Intra-gastric floating beads of naringenin were acquired successfully. More than 70% of the beads kept floating in artificial gastric juice in 9 h, the release ratio of naringenin during 9 h was 65%-70% and the entrapment efficiency was about 70%-80%.
The sustained release of naringenin in the calcium alginate-chitosan intra-gastric floating beads could be achieved by using the solid dispersion method and it provides some ideas of intra-gastric floating preparations.
采用固体分散技术制备柚皮苷海藻酸钠 - 壳聚糖胃内漂浮微丸，并考察微丸的体外漂浮特性、包封率及释药性能。
以尤特奇RLPO制备柚皮苷固体分散体，将其粉末与海藻酸钠溶液、起泡剂混合后缓慢滴入加有醋酸的壳聚糖 - 氯化钙溶液中，干燥后得到柚皮苷海藻酸钠 - 壳聚糖胃内漂浮微丸，考察固体分散体对柚皮苷体外释放的影响。
成功制备出柚皮苷胃内漂浮微丸。9 h内70%以上微丸在人工胃液中保持漂浮状态，9 h内柚皮苷释放率为65% - 70%，包封率约为70% - 80%。
采用固体分散技术可实现柚皮苷在海藻酸钠 - 壳聚糖胃内漂浮微丸中的缓释，为胃内漂浮制剂提供了思路。
