Department of Oncologic Sciences, Mitchell Cancer Institute, University of South Alabama, AL, USA.
Future Oncol. 2010 Jan;6(1):111-6. doi: 10.2217/fon.09.128.
The incidence of melanoma is rising at an alarming rate and we are still awaiting an effective treatment for this malignancy. In its early stage, melanoma can be cured by surgical removal, but once metastasis has occurred there is no effective treatment. Recent findings have suggested multiple functional implications of CXCL8 and its cognate receptors, CXCR1 and CXCR2, in melanoma pathogenesis, thus underscoring their importance as targets for cancer therapy. This review provides an update on the roles of CXCL8 and its receptors in melanoma progression and metastasis.
黑色素瘤的发病率正在以惊人的速度上升，而我们仍在等待这种恶性肿瘤的有效治疗方法。在早期阶段，黑色素瘤可以通过手术切除来治愈，但一旦发生转移，就没有有效的治疗方法。最近的研究结果表明，CXCL8 及其同源受体 CXCR1 和 CXCR2 在黑色素瘤发病机制中具有多种功能意义，因此强调了它们作为癌症治疗靶点的重要性。本文综述了 CXCL8 及其受体在黑色素瘤进展和转移中的作用。
