Komatsu Fumio, Kagawa Yasuo, Kawabata Terue, Kaneko Yoshinori, Ishiguro Kiyomi
Kagawa Nutrition University, 3-9-21, Chiyoda, Sakado, Saitama, 350-0288, Japan.
Curr Aging Sci. 2009 Dec;2(3):214-22. doi: 10.2174/1874609810902030214.
The Republic of Palau belongs to Micronesia, and obese people and lifestyle-related diseases are prevalent there. We investigated the relationship of dietary habits and obesity to oxidative stress in Palauan people, as compared with those of Japanese and Mongolian people. A total of 126 healthy Palauan subjects were enrolled. Oxidative stress was evaluated by serum level of reactive oxygen metabolites (ROM). Antioxidant capacity was evaluated by serum level of biological antioxidant potential (BAP). In Palauan subjects, BMI> or =30 was observed in 45.0% of males and 59.1% of females (Japanese: males 1.3%, females 0.8%, Mongolian: males 6.3%, females 14.7%). Palauan subjects consumed 2553 kcal per day (Japanese 2121 kcal, Mongolians 2534 kcal). The ratios of carbohydrate energy to total energy were 59.8 % (Japanese 54.7 %, Mongolians 50.2%). The ratios of fat energy to total energy were 22.9% (Japanese 26.7%, Mongolians 34.5%). ROM levels in Palauan subjects showed higher than those in Japanese subjects, while BAP levels of Palauan subjects did not decrease compared to those of Japanese. ROM levels correlated with body fat ratio, and showed a reverse correlation with handgrip strength. Handgrip strength decreased in the subjects of more than forty years of age. These findings suggest that the obesity in Palauan people may have a connection with high intake of calories through carbohydrate eating rather than through fat eating. Their high oxidative stress may be induced by obesity, and contribute to an early decline of handgrip strength, ultimately in early aging.
帕劳共和国属于密克罗尼西亚，肥胖人群和与生活方式相关的疾病在那里很普遍。我们调查了帕劳人与日本人和蒙古人相比，饮食习惯和肥胖与氧化应激之间的关系。总共招募了126名健康的帕劳受试者。通过血清活性氧代谢产物（ROM）水平评估氧化应激。通过血清生物抗氧化能力（BAP）水平评估抗氧化能力。在帕劳受试者中，45.0%的男性和59.1%的女性BMI≥30（日本人：男性1.3%，女性0.8%；蒙古人：男性6.3%，女性14.7%）。帕劳受试者每天摄入2553千卡热量（日本人2121千卡，蒙古人2534千卡）。碳水化合物能量占总能量的比例为59.8%（日本人54.7%，蒙古人50.2%）。脂肪能量占总能量的比例为22.9%（日本人26.7%，蒙古人34.5%）。帕劳受试者的ROM水平高于日本受试者，而帕劳受试者的BAP水平与日本受试者相比没有下降。ROM水平与体脂率相关，与握力呈负相关。40岁以上受试者的握力下降。这些发现表明，帕劳人的肥胖可能与通过碳水化合物而非脂肪摄入高热量有关。他们的高氧化应激可能由肥胖引起，并导致握力过早下降，最终导致早衰。
