高脂血症：糖尿病周围神经病变的新治疗靶点。
Hyperlipidemia: a new therapeutic target for diabetic neuropathy.
机构信息
Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
J Peripher Nerv Syst. 2009 Dec;14(4):257-67. doi: 10.1111/j.1529-8027.2009.00237.x.
Abstract
Emerging data establish dyslipidemia as a significant contributor to the development of diabetic neuropathy. In this review, we discuss how separate metabolic imbalances, including hyperglycemia and hyperlipidemia, converge on mechanisms leading to oxidative stress in dorsal root ganglia (DRG) sensory neurons. We conclude with suggestions for novel therapeutic strategies to prevent or reverse diabetes-induced nerve degeneration.
摘要
新出现的数据表明，血脂异常是糖尿病性神经病发展的一个重要因素。在这篇综述中，我们讨论了包括高血糖和高血脂在内的不同代谢失衡如何汇聚到导致背根神经节（DRG）感觉神经元氧化应激的机制。最后，我们提出了一些新的治疗策略，以预防或逆转糖尿病引起的神经变性。
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