Mai Jin-zhuang, Zhao Lian-cheng, Liu Xiao-qing, Wu Yang-feng, Rao Xu-xu, Gao Xiang-min, Wu Yong
Department of Epidemiology, Guangdong Provincial Cardiovascular Institute, Guangdong General Hospital, Guangzhou 510080, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Aug;37(8):750-3.
To evaluate the association between resting heart rate (HR) and all-cause death and coronary heart disease (CHD) events in the Chinese cohort.
Data were obtained from the PRC-USA Cooperative Study on Cardiovascular and Cardiopulmonary Epidemiology. Baseline screen surveys were conducted in 1983 and 1984 from people aged 35 to 59 years living in urban or rural areas of Beijing and Guangzhou. Follow-up visits were performed for end point events of all-cause death and first CHD events every two years till 2005. Resting HR was determined from 5 consecutive intervals between R waves on the 12-lead electrocardiogram.
A total of 9856 (4805 males) people were included in the study and the mean follow up duration was 16.2 years. There were 1523 deaths, including 200 CHD events during the follow up period. Mean resting HR was 67.9 beat per minute (bpm) in men and 71.6 bpm in women respectively which had a trend to increase with aging. Cox Proportional Hazards model indicated the relative risk of all-cause death increased constantly with the increase of HR percentile after control of age, fasting glucose, serum cholesterol, serum triglyceride, body mass index, systolic blood pressure and diastolic blood pressure. With HR 60-89 bpm as control group, the relative risk and 95% confidence interval in group HR < 50 bpm, 50 - 59 bpm, 90 - 99 bpm and > or = 100 bpm were 0.76 (0.49 - 1.17), 0.87 (0.75 - 1.02), 1.33 (1.06 - 1.68), 1.48 (1.03 - 2.14) respectively. However there was no significant correlation between HR and CHD events in studied population.
The risk of total death increased significantly in people with HR > or = 90 bpm suggesting higher resting heart rate might be an independent risk factor for all-cause death in the Chinese population.
评估中国队列中静息心率（HR）与全因死亡及冠心病（CHD）事件之间的关联。
数据来自中美心血管和心肺流行病学合作研究。1983年和1984年对居住在北京和广州城乡地区的35至59岁人群进行了基线筛查调查。每两年进行一次随访，直至2005年，记录全因死亡和首次冠心病事件等终点事件。静息心率通过12导联心电图上R波之间连续5个间期来确定。
共有9856人（4805名男性）纳入研究，平均随访时间为16.2年。随访期间有1523例死亡，其中包括200例冠心病事件。男性静息心率平均为67.9次/分钟（bpm），女性为71.6 bpm，且均有随年龄增长而升高的趋势。Cox比例风险模型显示，在控制年龄、空腹血糖、血清胆固醇、血清甘油三酯、体重指数、收缩压和舒张压后，全因死亡的相对风险随心率百分位数的增加而持续上升。以心率60 - 89 bpm为对照组，心率<50 bpm、50 - 59 bpm、90 - 99 bpm和≥100 bpm组的相对风险及95%置信区间分别为0.76（0.49 - 1.17）、0.87（0.75 - 1.02）、1.33（1.06 - 1.68）、1.48（1.03 - 2.14）。然而，在研究人群中，心率与冠心病事件之间无显著相关性。
心率≥90 bpm者全因死亡风险显著增加，提示静息心率较高可能是中国人群全因死亡的独立危险因素。
