酒精中毒患者脑代谢物变化：枕叶局部质子磁共振波谱研究。
Brain metabolite changes in alcoholism: localized proton magnetic resonance spectroscopy study of the occipital lobe.
机构信息
NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences (DRDO), Lucknow Road, Timarpur, Delhi 110054, India.
出版信息
Eur J Radiol. 2011 Jul;79(1):96-100. doi: 10.1016/j.ejrad.2009.11.003. Epub 2009 Dec 17.
Chronic alcoholism is associated with altered brain metabolism, morphology and cognitive abilities. Besides deficits in higher order cognitive functions, alcoholics also show a deficit in the processing of basic sensory information viz. visual stimulation. To assess the metabolic changes associated with this deficit, (1)H MRS was carried out in the occipital lobe of alcohol dependents. A significant increase in Cho/Cr ratio (p<0.015) was observed in occipital lobe in the alcoholic group indicating altered cell membrane metabolism, which may probably be associated with the alterations in the cognitive abilities associated with vision.
慢性酒精中毒与大脑代谢、形态和认知能力的改变有关。除了高级认知功能的缺陷外，酗酒者在处理基本感官信息（如视觉刺激）方面也存在缺陷。为了评估与这种缺陷相关的代谢变化，对酒精依赖者的枕叶进行了 (1)H MRS 检测。在酒精组中，观察到枕叶部位 Cho/Cr 比值显著升高（p<0.015），表明细胞膜代谢发生改变，这可能与与视觉相关的认知能力的改变有关。
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