Modi Shilpi, Bhattacharya Manisha, Sekhri Tarun, Rana Poonam, Tripathi Rajendra P, Khushu Subash
NMR Research Centre, INMAS, Timarpur, Delhi 110054, India.
Magn Reson Imaging. 2008 Apr;26(3):420-5. doi: 10.1016/j.mri.2007.08.011.
The metabolic changes in the brain of patients affected with Type 2 diabetes mellitus (DM) alone, both Type 2 DM and hypothyroidism and hypothyroidism only were investigated using proton magnetic resonance spectroscopy ((1)H MRS). Single-voxel spectroscopy was carried out in right and left frontal lobe white matter, left parietal white matter and left occipital gray matter. Choline (Cho)/creatine (Cr) value was found to be increased in the left occipital gray matter of the subjects affected with Type 2 DM and both Type 2 DM and hypothyroidism as compared to controls. No significant change in the Cho/Cr value in the occipital gray matter was observed in hypothyroid subjects as compared to controls. However, they showed an increased level of Cho/Cr in the frontal white matter. High Cho is associated with altered membrane phospholipid metabolism. The high Cho in frontal white matter in hypothyroids and occipital gray matter in diabetic patients suggests that, though both the diseases are endocrine disorders, they differ from each other in terms of regional brain metabolite changes.
利用质子磁共振波谱（¹H MRS）研究了仅患有2型糖尿病（DM）、同时患有2型DM和甲状腺功能减退症以及仅患有甲状腺功能减退症患者大脑中的代谢变化。在左右额叶白质、左顶叶白质和左枕叶灰质中进行了单体素质子磁共振波谱分析。与对照组相比，发现2型DM患者以及同时患有2型DM和甲状腺功能减退症患者的左枕叶灰质中胆碱（Cho）/肌酸（Cr）值升高。与对照组相比，甲状腺功能减退症患者枕叶灰质中的Cho/Cr值未观察到显著变化。然而，他们额叶白质中的Cho/Cr水平升高。高Cho与膜磷脂代谢改变有关。甲状腺功能减退症患者额叶白质和糖尿病患者枕叶灰质中的高Cho表明，尽管这两种疾病都是内分泌紊乱，但它们在区域脑代谢物变化方面彼此不同。
