Department of Biochemistry, New Biochemistry Building, The University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Curr Opin Cell Biol. 2010 Feb;22(1):112-9. doi: 10.1016/j.ceb.2009.11.011.
The intracellular localization of mRNA is an important mechanism for targeting proteins to their sites of function. Localized transcripts play key roles ranging from body axis determination to synapse plasticity, and recent studies highlight how common localized transcripts are in a variety of model organisms. In this review, we consider the full range of known mechanisms for delivering transcripts and anchoring them at their site of function. Finally, we evaluate the progress that has been made in the nervous system in understanding the mechanism and function of mRNA localization and translation regulation.
mRNA 的细胞内定位是将蛋白质靶向其功能部位的重要机制。定位于特定部位的转录本发挥着从体轴决定到突触可塑性等多种关键作用，最近的研究强调了在各种模式生物中常见的定位于特定部位的转录本的普遍性。在这篇综述中，我们考虑了已知的用于传递转录本并将其锚定在其功能部位的所有机制。最后，我们评估了在神经系统中理解 mRNA 定位和翻译调控的机制和功能方面所取得的进展。
