Department of Obstetrics and Gynecology, Charles University, Medical School and University, Hradec Kralove, Czech Republic.
Int J Gynaecol Obstet. 2010 Mar;108(3):203-6. doi: 10.1016/j.ijgo.2009.10.018. Epub 2009 Dec 21.
To determine whether amniotic fluid levels of pentraxin 3 (PTX3) are of value in the prenatal diagnosis of acute histological chorioamnionitis in preterm premature rupture of membranes (PPROM).
Forty pregnant women with PPROM between 24 and 36 weeks of pregnancy without (n=21) and with (n=19) histological chorioamnionitis (PPROM group) and 42 women between 16 and 20 weeks of pregnancy (midtrimester group) were included in the study. We compared amniotic fluid PTX3 levels in the PPROM group with versus without histological chorioamnionitis, and between the PPROM and the midtrimester groups using nonparametric tests (Mann-Whitney test), given the non-normal distribution of the analyte.
Patients with histological chorioamnionitis had a significantly higher median amniotic fluid PTX3 concentration than patients without the histological signs of chorioamnionitis (3.69ng/mL [0.51-106.8] versus 0.8ng/mL [0.36-121.0]; P=0.015). Patients in the PPROM group reached a significantly higher median amniotic fluid concentration of PTX3 compared with those in the midtrimester group (1.0ng/mL [0.36-121.0] versus 0.67ng/mL [0.4-2.8]; P=0.007).
Histological chorioamnionitis is associated with a significant increase of amniotic fluid pentraxin 3 levels. Amniotic fluid pentraxin 3 appears to be a marker of intra-amniotic inflammation.
探讨五聚素 3（PTX3）在预测未足月胎膜早破孕妇发生急性组织学绒毛膜羊膜炎中的价值。
本研究纳入了 40 例孕 24-36 周未足月胎膜早破且无（n=21）或有（n=19）组织学绒毛膜羊膜炎的孕妇（PPROM 组），以及 42 例孕 16-20 周的孕妇（中期妊娠组）。采用非参数检验（Mann-Whitney 检验）比较 PPROM 组有无组织学绒毛膜羊膜炎及与中期妊娠组的羊水中 PTX3 水平。由于分析物呈非正态分布，因此采用了该检验。
有组织学绒毛膜羊膜炎的患者羊水中 PTX3 浓度中位数显著高于无组织学绒毛膜羊膜炎的患者（3.69ng/mL [0.51-106.8]与 0.8ng/mL [0.36-121.0]；P=0.015）。PPROM 组患者羊水中 PTX3 浓度中位数显著高于中期妊娠组（1.0ng/mL [0.36-121.0]与 0.67ng/mL [0.4-2.8]；P=0.007）。
组织学绒毛膜羊膜炎与羊水五聚素 3 水平显著升高相关。羊水五聚素 3 似乎是羊膜内炎症的标志物。
