Kacerovsky Marian, Drahosova Marcela, Andrys Ctirad, Hornychova Helena, Tambor Vojtech, Lenco Juraj, Tosner Jindrich, Krejsek Jan
Department of Obstetrics and Gynecology, Charles University in Prague, Faculty of Medicine Hradec Kralove, University Hospital Hradec Kralove, Czech Republic.
J Matern Fetal Neonatal Med. 2011 Aug;24(8):995-1001. doi: 10.3109/14767058.2010.538453. Epub 2010 Dec 15.
To determine changes in the amniotic fluid, soluble form of scavenger receptor for hemoglobin (sCD163) concentrations during advancing gestation, and in patients with preterm premature rupture of membranes (PPROM) complicated by histological chorioamnionitis were studied.
One hundred and fifty-two women with singleton pregnancies were enrolled. The concentration of sCD163 in amniotic fluid was determined using sandwich enzyme immunoassay technique.
Women in the midtrimester had a significantly higher median amniotic fluid sCD163 concentration than those at term not in labor (308 ng/ml vs. 217 ng/ml; p = 0.04). Patients with PPROM and histological chorioamnionitis had a higher median amniotic fluid sCD163 level than those with PPROM without histological chorioamnionitis (885 ng/ml vs. 288 ng/ml; p < 0.0001).
Amniotic fluid sCD163 concentrations decrease with advancing gestation. Amniotic fluid sCD163 concentrations are significantly higher in women with PPROM between 24 and 36 gestational weeks with histological chorioamnionitis than those without histological signs of inflammation.
确定妊娠进展过程中羊水、血红蛋白清除受体可溶性形式（sCD163）浓度的变化，并对合并组织学绒毛膜羊膜炎的胎膜早破（PPROM）患者进行研究。
纳入152名单胎妊娠女性。采用夹心酶免疫测定技术测定羊水中sCD163的浓度。
孕中期女性羊水sCD163浓度中位数显著高于足月未临产者（308 ng/ml对217 ng/ml；p = 0.04）。合并组织学绒毛膜羊膜炎的PPROM患者羊水sCD163水平中位数高于无组织学绒毛膜羊膜炎的PPROM患者（885 ng/ml对288 ng/ml；p < 0.0001）。
羊水sCD163浓度随妊娠进展而降低。妊娠24至36周合并组织学绒毛膜羊膜炎的PPROM女性羊水sCD163浓度显著高于无炎症组织学征象者。
