Department of Physiology and Radiobiology, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia.
Res Vet Sci. 2010 Jun;88(3):405-10. doi: 10.1016/j.rvsc.2009.11.008. Epub 2009 Dec 21.
Pregnancy and lactation are periods of significant influence on bone metabolism that has not been investigated in equines. To examine the influence of late pregnancy and lactation on bone metabolism in mares, the changes in the blood serum/plasma total calcium (Ca), inorganic phosphates (Pi), pyridinoline (Pyd) and 17beta-estradiol (E2) concentration and the bone alkaline phosphatase (BAP) activity were investigated. The samples were taken from 11 mares on 60+/-10 and 20+/-10 days before foaling, and 20+/-10 and 60+/-10 days after foaling. The concentration/activity of Ca, Pi, Pyd and BAP increased significantly in early lactation, but the Pyd than decreased in the 4th period. A significant correlation was observed between the E2 and bone metabolism parameters. The results indicate low maintenance of normocalcaemia with reduced bone synthesis in late pregnancy and prove the role of estradiol in bone metabolism in mares during pregnancy and lactation.
妊娠和哺乳期是对骨骼代谢有重大影响的时期，但在马属动物中尚未进行研究。为了研究妊娠晚期和哺乳期对母马骨骼代谢的影响，检测了血清/血浆总钙（Ca）、无机磷（Pi）、吡啶酚（Pyd）和 17β-雌二醇（E2）浓度以及骨碱性磷酸酶（BAP）活性的变化。于产前 60±10 天和 20±10 天、产后 20±10 天和 60±10 天从 11 匹母马采集样本。Ca、Pi、Pyd 和 BAP 的浓度/活性在哺乳期早期显著增加，但第 4 期 Pyd 降低。E2 和骨代谢参数之间存在显著相关性。结果表明，妊娠晚期维持正常血钙水平的能力降低，骨合成减少，并证明了雌二醇在妊娠和哺乳期母马骨骼代谢中的作用。
