Department of Biochemistry Biology and Genetics, Polytechnic University of Marche, Via Ranieri, 60100 Ancona, Italy.
Neurobiol Aging. 2011 Nov;32(11):2103-5. doi: 10.1016/j.neurobiolaging.2009.11.016. Epub 2009 Dec 21.
Down syndrome (DS) is a chromosomal abnormality (trisomy 21) associated with a complex phenotype. Oxidative stress is known to play a major role in this pathology both due to genetic and epigenetic factors, suggesting that oxidative imbalance contributes to the clinical manifestation of DS. In particular, the implications of oxidative DNA damage in Down syndrome has been linked with neurodegeneration. Here we report the results of a double blind controlled trial aimed at investigating the protective effect of Coenzyme Q(10) on DNA oxidation in this clinical setting using the single cell gel electrophoresis technique.
唐氏综合征（DS）是一种与复杂表型相关的染色体异常（三体 21）。由于遗传和表观遗传因素，氧化应激在这种病理中起着重要作用，这表明氧化失衡导致了 DS 的临床表现。特别是，氧化 DNA 损伤在唐氏综合征中的意义与神经退行性变有关。在这里，我们报告了一项旨在使用单细胞凝胶电泳技术在这种临床情况下研究辅酶 Q(10)对 DNA 氧化的保护作用的双盲对照试验的结果。
