Columbia University, New York Obesity Research Center, St. Lukes-Roosevelt Hospital Center, New York, New York, USA.
J Arthroplasty. 2010 Dec;25(8):1290-4. doi: 10.1016/j.arth.2009.09.001. Epub 2009 Dec 21.
Self-reported studies have demonstrated efficacy of hyaluronic acid (HA) therapy. Gait analysis may objectively demonstrate changes associated with HA therapy. Fifty-three consecutive patients with unilateral osteoarthritis (OA) of the knee were evaluated with a validated and sensitive gait laboratory previously used for gonarthrosis. Two 100-meter walks were performed before and after HA therapy. Nineteen parameters were measured. In addition, the subjective response to treatment was correlated with changes in gait parameters. Single-limb support time, velocity, fatigability, and swing phase were not improved. Only double-limb support time was found to be significantly different (P = .04). The remaining gait variables were not changed. Separately, the subset of patients that achieved greater than 70% subjective pain relief had no objective improvements in gait parameters. Hyaluronic acid therapy may result in a placebo effect for the treatment of gonarthrosis.
自我报告的研究已经证明了透明质酸 (HA) 治疗的疗效。步态分析可以客观地显示与 HA 治疗相关的变化。53 例单侧膝关节骨关节炎 (OA) 患者采用以前用于膝关节骨关节炎的经过验证和敏感的步态实验室进行评估。在 HA 治疗前后进行了两次 100 米行走测试。测量了 19 个参数。此外，治疗的主观反应与步态参数的变化相关。单腿支撑时间、速度、疲劳性和摆动阶段没有改善。只有双腿支撑时间有显著差异 (P =.04)。其余的步态变量没有改变。另外，那些达到 70%以上主观疼痛缓解的患者亚组在步态参数上没有得到客观改善。透明质酸治疗可能对膝关节骨关节炎的治疗产生安慰剂效应。
