Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Hospital Universitari Vall d'Hebron, Department of Medicine, Universitat Autonoma, Barcelona, Spain.
Med Clin (Barc). 2010 Apr 10;134(10):433-8. doi: 10.1016/j.medcli.2009.09.040. Epub 2009 Dec 22.
The aim was to evaluate the role of anti-annexin A5 (anti-ANXA5) antibodies as risk factor for recurrent miscarriage (RM) and unexplained fetal loss (UFL).
Retrospective, cohort study.
Vall d'Hebron University Hospital.
122 women, in two groups:
54 women with RM/UFL and control group: 68 pregnant without RM/UFL.
Antiphospholipid, mainly anti-ANXA5 antibody analysis. Comparison of all antiphospholipid antibodies between groups.
Antiphospholipid antibody (aPL) prevalence in the study group was 10/54 (14.8%) and 5/68 (7.3%) in control group (p=0.09). In the RM subgroup, it was 3/25 and 9/34 in UFL versus 5/68 in controls (p=0.013). Lupus anticoagulant (LA) was present in 4 cases, all belonging to the study group (p=0.011). Four out of 34 women with UFL were positive for anticardiolipin antibodies-IgG (IgG-aCL) versus 1/68 in controls (p=0.041). In RM subgroup, anti-ANXA5 antibodies were positive in 2/25 versus 3/68 in controls, and in UFL subgroup, 3/34 versus 3/68 cases (p=1.000).
According to our results, anti-ANXA5 antibodies should not be considered as a risk factor for RM/UFL.
本研究旨在评估抗膜联蛋白 A5（anti-ANXA5）抗体作为复发性流产（RM）和不明原因胎儿丢失（UFL）的风险因素的作用。
回顾性队列研究。
瓦尔登大学医院。
122 名女性，分为两组：
54 名 RM/UFL 患者；对照组：68 名未发生 RM/UFL 的妊娠患者。
抗磷脂抗体，主要是抗-ANXA5 抗体分析。比较两组之间的所有抗磷脂抗体。
研究组抗磷脂抗体（aPL）的患病率为 10/54（14.8%），对照组为 5/68（7.3%）（p=0.09）。在 RM 亚组中，25 例 RM 中有 3 例，34 例 UFL 中有 9 例，而对照组有 5 例（p=0.013）。狼疮抗凝物（LA）存在于 4 例中，均属于研究组（p=0.011）。在 UFL 中，有 4 例抗心磷脂抗体 IgG（IgG-aCL）阳性，而对照组有 1 例（p=0.041）。在 RM 亚组中，25 例 RM 中有 2 例抗-ANXA5 抗体阳性，而对照组有 68 例中的 3 例，在 UFL 亚组中，34 例中有 3 例，而对照组有 68 例中的 3 例（p=1.000）。
根据我们的结果，抗-ANXA5 抗体不应被视为 RM/UFL 的风险因素。
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