Arnold J, Holmes Z, Pickering W, Farmer C, Regan L, Cohen H
Department of Haematology, St Mary's Hospital, University College London Hospitals NHS Trust, London, UK.
Br J Haematol. 2001 Jun;113(4):911-4. doi: 10.1046/j.1365-2141.2001.02812.x.
While it has been established that anti-phospholipid antibodies (aPL) are associated with recurrent miscarriage (RM), the importance of anti-beta2 glycoprotein 1 (GP1) IgG and anti-annexin V IgG antibodies as risk factors for RM is undefined. We have investigated the prevalence of anti-beta2 GP1 IgG and anti-annexin V IgG antibodies in 54 aPL-positive and 48 aPL-negative women with RM. The prevalence of IgG anti-beta2 GP1 antibodies was not significantly different in persistently aPL-positive women with RM (7%), aPL-negative women with RM (6%) and the normal parous control group (3%). Anti-annexin V IgG antibody prevalence was significantly increased in aPL-positive women with RM compared with aPL-negative women with RM (P = 0.01). The elevations were found in 35%, 19% and 16% of aPL-positive women with RM, aPL-negative women with RM and the control group respectively. No women showed positivity for both anti-beta2 GP1 IgG and anti-annexin V antibodies. Anti-beta2 GP1 IgG antibodies do not appear to be contributory to the investigation of women with RM. Anti-annexin V antibody positivity, although associated with aPL positivity in women with RM, is not an independent risk marker.
虽然已经确定抗磷脂抗体（aPL）与复发性流产（RM）相关，但抗β2糖蛋白1（GP1）IgG和抗膜联蛋白V IgG抗体作为RM风险因素的重要性尚不清楚。我们调查了54例aPL阳性和48例aPL阴性的RM女性中抗β2 GP1 IgG和抗膜联蛋白V IgG抗体的患病率。RM的持续aPL阳性女性（7%）、RM的aPL阴性女性（6%）和正常经产妇对照组（3%）中IgG抗β2 GP1抗体的患病率无显著差异。与RM的aPL阴性女性相比，RM的aPL阳性女性中抗膜联蛋白V IgG抗体患病率显著升高（P = 0.01）。RM的aPL阳性女性、RM的aPL阴性女性和对照组中分别有35%、19%和16%出现升高。没有女性同时出现抗β2 GP1 IgG和抗膜联蛋白V抗体阳性。抗β2 GP1 IgG抗体似乎对RM女性的调查没有贡献。抗膜联蛋白V抗体阳性虽然与RM女性的aPL阳性相关，但不是一个独立的风险标志物。
