Systemic Autoimmune Disease Unit, Department of Internal Medicine I, Vall d'Hebron University Hospital, Barcelona, Spain.
Fertil Steril. 2010 May 1;93(7):2330-6. doi: 10.1016/j.fertnstert.2009.01.089. Epub 2009 Mar 17.
To evaluate the role of anti-beta(2)-glycoprotein-I (anti-beta(2)GPI-ab) and anti-phosphatidylserine (aPS-ab) antibodies as a risk factor in both recurrent miscarriage (RM) and unexplained fetal losses (UFL).
Retrospective, cohort study.
Vall d'Hebron University Hospital, Barcelona, Spain.
PATIENT(S): 122 pregnant women divided in two groups: study group of 54 women with RM and/or UFL and control group of 68 pregnant without RM history.
INTERVENTION(S): Analysis of lupus anticoagulant, anticardiolipin antibodies, and anti-beta(2)GP1 and aPS antibodies.
MAIN OUTCOME MEASURE(S): Comparison of aPL antibody between groups.
RESULT(S): The prevalence of aPL positive results was 8 out of 54 (14.8%) in the study group and 3 out of 68 (4.41%) in the controls. In the RM subgroup, the prevalence was 3 out of 25 (12%) versus 3 out of 68 (4.4%), and 7 out of 34 (20.6%) versus 3 out of 68 (4.4%) in UFL subgroup. As a whole, the prevalence of anti-beta(2)GP1-ab in the RM/UFL group showed a difference compared with controls but not aPS-ab. In the RM women, anti-beta(2)GP1-ab was positive in 3 out of 25 (12%) versus 1 out of 68 (1.5%) in controls and in 4 out of 34 versus 0 out of 68 cases in women with UFL. In the RM subgroup, aPS-ab was positive in 1 out of 25 (4%) versus 2 out of 68 (2.9%) in control group and in 3 out of 34 versus 2 out of 68 cases in women with UFL.
CONCLUSION(S): Our results suggest that anti-beta(2)GP1-ab but not aPS-ab is related to RM/UFL and should be considered as a pregnancy-loss risk factor.
评估抗β2-糖蛋白 I（抗β2GPI-ab）和抗磷脂酰丝氨酸（aPS-ab）抗体作为复发性流产（RM）和不明原因胎儿丢失（UFL）的风险因素的作用。
回顾性队列研究。
西班牙巴塞罗那 Vall d'Hebron 大学医院。
122 名孕妇分为两组：研究组 54 名 RM 和/或 UFL 孕妇和对照组 68 名无 RM 史的孕妇。
分析狼疮抗凝物、抗心磷脂抗体以及抗β2 糖蛋白 I 和 aPS 抗体。
比较两组 aPL 抗体。
研究组中 aPL 阳性结果的发生率为 8 例（14.8%），对照组为 3 例（4.41%）。在 RM 亚组中，发生率为 25 例中的 3 例（12%）与 68 例中的 3 例（4.4%），34 例 UFL 亚组中的 7 例与 68 例中的 3 例（4.4%）。整体而言，RM/UFL 组抗β2 糖蛋白 I-ab 的发生率与对照组相比有差异，但 aPS-ab 无差异。在 RM 女性中，抗β2 糖蛋白 I-ab 阳性率为 25 例中的 3 例（12%），对照组为 68 例中的 1 例（1.5%），34 例 UFL 中的 4 例，对照组为 0 例。在 RM 亚组中，aPS-ab 阳性率为 25 例中的 1 例（4%），对照组为 68 例中的 2 例（2.9%），34 例 UFL 中的 3 例，对照组为 2 例。
我们的结果表明，抗β2 糖蛋白 I-ab 而非 aPS-ab 与 RM/UFL 相关，应被视为妊娠丢失的风险因素。
