Department of Molecular and Cell Biology, UC-Berkeley, United States.
Curr Opin Cell Biol. 2010 Feb;22(1):36-43. doi: 10.1016/j.ceb.2009.11.009. Epub 2009 Dec 21.
Membrane curvature has emerged as a key regulatory factor in endocytic vesicle formation. From a theoretical perspective, we summarize recent progress in understanding how membrane curvature and biochemical pathways are coupled and orchestrated during the coherent process of endocytic vesicle formation. We mainly focus on clathrin-mediated and actin-mediated endocytosis in yeast and in mammalian cells. We further speculate on how mechanochemical feedback could modulate other membrane-remodeling processes.
膜曲率已成为内吞小泡形成的关键调节因子。从理论角度来看,我们总结了近期在理解膜曲率和生化途径如何在连贯的内吞小泡形成过程中耦合并协调方面的进展。我们主要关注酵母和哺乳动物细胞中的网格蛋白介导和肌动蛋白介导的内吞作用。我们进一步推测机械化学反馈如何调节其他的膜重塑过程。