持续有氧运动对内皮功能的影响：随机对照试验的系统评价和荟萃分析
Effect of continuous aerobic exercise on endothelial function: A systematic review and meta-analysis of randomized controlled trials.
作者信息
Tao Xifeng, Chen Yiyan, Zhen Kai, Ren Shiqi, Lv Yuanyuan, Yu Laikang
机构信息
Key Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, China.
Department of Sports Performance, Beijing Sport University, Beijing, China.
出版信息
Front Physiol. 2023 Feb 10;14:1043108. doi: 10.3389/fphys.2023.1043108. eCollection 2023.
Current research suggests that continuous aerobic exercise can be effective in improving vascular endothelial function, while the effect between different intensities and durations of exercise is unclear. The aim of this study was to explore the effect of different durations and intensities of aerobic exercise on vascular endothelial function in different populations. Searches were performed in PubMed, Web of Science, and EBSCO databases. We included studies that satisfied the following criteria: 1) randomized controlled trials (RCTs); 2) including both an intervention and control group; 3) using flow-mediated dilation (FMD) as the outcome measure; and 4) testing FMD on the brachial artery. From 3,368 search records initially identified, 41 studies were eligible for meta-analysis. There was a significant effect of continuous aerobic exercise on improving flow-mediated dilation (FMD) [weighted mean difference (WMD), 2.55, (95% CI, 1.93-3.16), 0.001]. Specifically, moderate-intensity [2.92 (2.02-3.825), < 0.001] and vigorous-intensity exercise [2.58 (1.64-3.53), < 0.001] significantly increased FMD. In addition, a longer duration [<12 weeks, 2.25 (1.54-2.95), < 0.001; ≥12 weeks, 2.74 (1.95-3.54), < 0.001], an older age [age <45, 2.09 (0.78-3.40), = 0.002; 45 ≤ age <60, 2.25 (1.49-3.01), < 0.001; age ≥60, 2.62 (1.31-3.94), < 0.001], a larger basal body mass index (BMI) [20 < BMI < 25, 1.43 (0.98-1.88), 0.001; 25 ≤ BMI < 30, 2.49 (1.07-3.90), < 0.001; BMI ≥ 30, 3.05 (1.69-4.42), 0.001], and a worse basal FMD [FMD < 4, 2.71 (0.92-4.49), = 0.003; 4 ≤ FMD < 7, 2.63 (2.03-3.23), < 0.001] were associated with larger improvements in FMD. Continuous aerobic exercise, especially moderate-intensity and vigorous-intensity aerobic exercise, contributed to improving FMD. The effect of continuous aerobic exercise on improving FMD was associated with duration and participant's characteristics. Specifically, a longer duration, an older age, a larger basal BMI, and a worse basal FMD contributed to more significant improvements in FMD. : [https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=341442], identifier [CRD42022341442].
目前的研究表明，持续有氧运动可有效改善血管内皮功能，而不同强度和时长的运动之间的效果尚不清楚。本研究的目的是探讨不同时长和强度的有氧运动对不同人群血管内皮功能的影响。在PubMed、科学网和EBSCO数据库中进行了检索。我们纳入了符合以下标准的研究：1）随机对照试验（RCT）；2）包括干预组和对照组；3）使用血流介导的血管舒张（FMD）作为结局指标；4）在肱动脉上检测FMD。从最初识别出的3368条检索记录中，有41项研究符合荟萃分析的条件。持续有氧运动对改善血流介导的血管舒张（FMD）有显著效果[加权平均差（WMD），2.55，（95%置信区间，1.93 - 3.16），P = 0.001]。具体而言，中等强度运动[2.92（2.02 - 3.825），P < 0.001]和高强度运动[2.58（1.64 - 3.53），P < 0.001]显著增加了FMD。此外，运动时长更长[<12周，2.25（1.54 - 2.95），P < 0.001；≥12周，2.74（1.95 - 3.54），P < 0.001]、年龄更大[年龄<45岁，2.09（0.78 - 3.40），P = 0.002；45≤年龄<60岁，2.25（1.49 - 3.01），P < 0.001；年龄≥60岁，2.62（1.31 - 3.94），P < 0.001]、基础体重指数（BMI）更高[20 < BMI < 25，1.43（0.98 - 1.88），P = 0.001；25≤BMI < 30，2.49（1.07 - 3.90），P < 0.001；BMI≥30，3.05（1.69 - 4.42），P = 0.001]以及基础FMD更差[FMD < 4，2.71（0.92 - 4.49），P = 0.003；4≤FMD < 7，2.63（2.03 - 3.23），P < 0.001]与FMD的更大改善相关。持续有氧运动尤其中等强度和高强度有氧运动有助于改善FMD。持续有氧运动对改善FMD的效果与运动时长和参与者特征相关。具体而言，更长的运动时长、更大的年龄更高的基础BMI以及更差的基础FMD有助于FMD有更显著的改善。：[https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=341442]，标识符[CRD42022341442]
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