Biology Department, Harvey Mudd College, 301 Platt Boulevard, Claremont, CA 91711, USA.
Development. 2010 Jan;137(1):5-13. doi: 10.1242/dev.036160.
Cis-regulatory modules are non-protein-coding regions of DNA essential for the control of gene expression. One class of regulatory modules is embryonic enhancers, which drive gene expression during development as a result of transcription factor protein binding at the enhancer sequences. Recent comparative studies have begun to investigate the evolution of the sequence architecture within enhancers. These analyses are illuminating the way that developmental biologists think about enhancers by revealing their molecular mechanism of function.
顺式调控模块是 DNA 中非编码蛋白的区域，对于基因表达的调控至关重要。调控模块的一类是胚胎增强子，它通过转录因子蛋白在增强子序列上的结合，在发育过程中驱动基因表达。最近的比较研究开始研究增强子中序列结构的进化。这些分析通过揭示增强子的分子功能机制，为发育生物学家思考增强子提供了新的视角。
