Institute for Genome Sciences & Policy, Departments of Biostatistics & Bioinformatics and Computer Science, Duke University, Durham, NC 27708, USA.
Development. 2010 Jan;137(1):15-26. doi: 10.1242/dev.035493.
Animal growth and development depend on the precise control of gene expression at the level of transcription. A central role in the regulation of developmental transcription is attributed to transcription factors that bind DNA enhancer elements, which are often located far from gene transcription start sites. Here, we review recent studies that have uncovered significant regulatory functions in developmental transcription for the TFIID basal transcription factors and for the DNA core promoter elements that are located close to transcription start sites.
动物的生长和发育取决于转录水平上基因表达的精确控制。转录因子在调节发育转录中起着核心作用,它们可以结合 DNA 增强子元件,而这些元件通常位于基因转录起始位点很远的地方。在这里,我们回顾了最近的研究,这些研究揭示了 TFIID 基本转录因子以及位于转录起始位点附近的 DNA 核心启动子元件在发育转录中的重要调节功能。