蛋白质和mRNA表达水平的整体特征
Global signatures of protein and mRNA expression levels.
作者信息
de Sousa Abreu Raquel, Penalva Luiz O, Marcotte Edward M, Vogel Christine
机构信息
Children's Cancer Research Institute, University of Texas Health Science Center at San Antonio, TX, USA.
出版信息
Mol Biosyst. 2009 Dec;5(12):1512-26. doi: 10.1039/b908315d. Epub 2009 Oct 1.
Abstract
Cellular states are determined by differential expression of the cell's proteins. The relationship between protein and mRNA expression levels informs about the combined outcomes of translation and protein degradation which are, in addition to transcription and mRNA stability, essential contributors to gene expression regulation. This review summarizes the state of knowledge about large-scale measurements of absolute protein and mRNA expression levels, and the degree of correlation between the two parameters. We summarize the information that can be derived from comparison of protein and mRNA expression levels and discuss how corresponding sequence characteristics suggest modes of regulation.
摘要
细胞状态由细胞蛋白质的差异表达决定。蛋白质与mRNA表达水平之间的关系反映了翻译和蛋白质降解的综合结果，而翻译和蛋白质降解除了转录和mRNA稳定性外，也是基因表达调控的重要因素。本综述总结了关于绝对蛋白质和mRNA表达水平大规模测量的知识现状，以及这两个参数之间的相关程度。我们总结了可从蛋白质和mRNA表达水平比较中获得的信息，并讨论了相应的序列特征如何提示调控模式。
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