钯催化的芳基卤化物与α-酮酰胺的分子内亲核加成合成 3-羟基氧吲哚。
Synthesis of 3-hydroxyoxindoles by Pd-catalysed intramolecular nucleophilic addition of aryl halides to alpha-ketoamides.
机构信息
Department of Organic Chemistry, University of Geneva, 30 Quai Ernest Ansermet, 1211 Geneva 4, Switzerland.
出版信息
Chem Commun (Camb). 2010 Jan 7;46(1):130-2. doi: 10.1039/b917958e. Epub 2009 Nov 3.
DOI:10.1039/b917958e
PMID:20024316
Abstract
Pd/PtBu(3)-catalysed intramolecular nucleophilic addition of aryl halides to alpha-ketoamides in the presence of nBuOH and base has been realized with high yields, providing a new, direct, and efficient synthetic strategy to obtain 3-hydroxyoxindoles.
摘要
Pd/PtBu(3)-催化的芳基卤化物与α-酮酰胺在 nBuOH 和碱存在下的分子内亲核加成反应已被实现，具有高产率，为获得 3-羟基吲哚提供了一种新的、直接的、有效的合成策略。
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