儿童脾切除术后免疫系统的改变。

Alterations of the immune system following splenectomy in childhood.

作者信息

Kreuzfelder E, Obertacke U, Erhard J, Funk R, Steinen R, Scheiermann N, Thraenhart O, Eigler F W, Schmit-Neuerburg K P

机构信息

Institut für Medizinische Virologie und Immunologie, Universitätsklinikum-GHS-Essen, F.R., Germany.

出版信息

J Trauma. 1991 Mar;31(3):358-64. doi: 10.1097/00005373-199103000-00008.

DOI:10.1097/00005373-199103000-00008

PMID:2002522

Abstract

After splenectomy due to blunt abdominal trauma, splenectomized children showed a restricted pattern of T-cell immunodeficiency compared to age and sex-matched normal children. Peripheral blood total (CD3) T-cell counts of 11 splenectomized children of 43%, double positive helper (CD4) inducer subpopulation (CD29) cell counts of nine splenectomized children of 7%, and phytohemagglutinin (PHA)-induced T-cell proliferation of 11 splenectomized children of 53,206 c.p.m. were significantly (p less than 0.05) lower than values of normal children (61% CD3 cells, n = 12; 13% CD4CD29 cells, n = 11; 107,832 c.p.m. PHA-induced proliferation, n = 12). The deficit of CD4CD29 cell numbers may be due to impaired maturation of these particular CD4 lymphocytes and may explain diminished PHA-induced proliferation in small children. The significantly higher B-lymphocyte counts of splenectomized children (21%, n = 11; 558 cells/mm3, n = 10) compared with 12 normal children (14%; 329 cells/mm3) may be due to loss of the reservoir function of the spleen.

摘要

在因钝性腹部创伤行脾切除术后，与年龄和性别匹配的正常儿童相比，脾切除儿童表现出T细胞免疫缺陷受限模式。11名脾切除儿童的外周血总（CD3）T细胞计数为43%，9名脾切除儿童的双阳性辅助（CD4）诱导亚群（CD29）细胞计数为7%，11名脾切除儿童的植物血凝素（PHA）诱导的T细胞增殖为53,206 c.p.m.，均显著（p小于0.05）低于正常儿童的值（61% CD3细胞，n = 12；13% CD4CD29细胞，n = 11；107,832 c.p.m. PHA诱导的增殖，n = 12）。CD4CD29细胞数量的不足可能是由于这些特定CD4淋巴细胞的成熟受损，这可能解释了年幼儿童PHA诱导增殖的减少。与12名正常儿童（14%；329个细胞/mm3）相比，脾切除儿童的B淋巴细胞计数显著更高（21%，n = 11；558个细胞/mm3，n = 10），这可能是由于脾脏储库功能丧失所致。