Spirer Z, Hauser G J, Hazaz B, Joshua H
Acta Haematol. 1980;63(4):230-3. doi: 10.1159/000207404.
Sera of 41 splenectomized subjects were tested for presence of autoantibodies by the indirect immunofluorescent method. 11 of them (26%) revealed the presence of one or more types of autoantibodies. Antiheart antibodies were the most common type (9 subjects). The incidence of antibodies was higher in the subjects splenectomized for trauma than in those who underwent elective splenectomy (39 and 25%, respectively). There was no significant difference between the subjects with positive and negative results with respect to mean age at examination, but the positive results tend to occur more frequently in those who underwent splenectomy at younger age. None of the subjects with any type of antibodies suffered from autoimmune disease. Although it is still impossible to evaluate the clinical importance of these findings, they suggest that splenectomy may disturb the regulatory processes in the immune system. We postulate that this is due to the reduction of the number of suppressor T cells for which the spleen is a major pool.
采用间接免疫荧光法检测了41例脾切除患者血清中自身抗体的存在情况。其中11例（26%）显示存在一种或多种类型的自身抗体。抗心脏抗体是最常见的类型（9例）。因创伤行脾切除的患者中抗体发生率高于择期脾切除患者（分别为39%和25%）。检查时平均年龄方面，结果阳性和阴性的患者之间无显著差异，但阳性结果在较年轻行脾切除的患者中更易出现。有任何类型抗体的患者均未患自身免疫性疾病。虽然仍无法评估这些发现的临床重要性，但它们提示脾切除可能会干扰免疫系统的调节过程。我们推测这是由于作为抑制性T细胞主要储存库的脾脏数量减少所致。
