Winkelmeyer M, Littmann K, Thraenhart O, Tichy G, Kuwert E K, Eigler F W
Klin Wochenschr. 1981 May 15;59(10):485-93. doi: 10.1007/BF01696210.
In twenty-seven splenectomized patients, who had undergone splenectomy for trauma (n=13) and thirty-one immunologically healthy persons, matched for age and sex, the following immunological parameters were examined: Serum immunoglobulins M, A, G, D and E, complement factors C3, C4 and the serum haemolytic complement activity (Ch 50), as well as the ratio and in vitro reagibility of B-and T-lymphocytes measured by transformation responses to the non-specific mitogens Phytohämagglutinin, Concanavalin A and Pokeweed-Mitogen. The phagocytic capacity of polymorphonuclear neutrophils was tested by the Nitroblue tetrazolium test. Total peripheral lymphocytes, B- und T-lymphocytes from splenectomized patients were significantly higher than in healthy controls (p less than 0.01). The PHA response in splenectomized patients was significantly depressed (p less than 0.01) as compared to nonsplenectomized controls. Also IgM serum concentration was found to be significantly lower in these patients (p less than 0.01). No differences were observed between patients, who had been splenectomized 7 months to 5 years or 6 to 14 years ago. The comparison of persons splenectomized for traumatological or haematological disorders showed statistically no significant differences. The importance of the spleen for the primary immune response is discussed.
在27例因创伤行脾切除术的患者（n = 13）和31名年龄及性别匹配的免疫功能正常者中，检测了以下免疫参数：血清免疫球蛋白M、A、G、D和E、补体因子C3、C4以及血清溶血补体活性（Ch 50），还有通过对非特异性有丝分裂原植物血凝素、刀豆球蛋白A和商陆有丝分裂原的转化反应来测定的B淋巴细胞和T淋巴细胞的比例及体外反应性。通过硝基蓝四氮唑试验检测多形核中性粒细胞的吞噬能力。脾切除患者的外周血总淋巴细胞、B淋巴细胞和T淋巴细胞明显高于健康对照组（p < 0.01）。与未行脾切除术的对照组相比，脾切除患者的PHA反应明显降低（p < 0.01）。这些患者的IgM血清浓度也明显较低（p < 0.01）。在7个月至5年前或6至14年前行脾切除术的患者之间未观察到差异。对因创伤或血液系统疾病行脾切除术的患者进行比较，统计学上无显著差异。讨论了脾脏对初次免疫反应的重要性。
