Department of Medical Oncology, Tumor Hospital of Harbin Medical University, Haping, Harbin, China.
Cancer Biother Radiopharm. 2009 Dec;24(6):675-80. doi: 10.1089/cbr.2009.0679.
The clinical use of cisplatin, a potent antineoplastic agent, is limited by its severe adverse effects. The present study was designed to evaluate the effects of resveratrol on cisplatin-induced cardiac injury. Resveratrol is a potent free radical scavenger. In the present study, we tested whether resveratrol would prevent cisplatin-induced cardiotoxicity in rats. Plasma-enzyme activities and histologic myocardial changes were examined. The anticancer role of resveratrol and/or cisplatin were measured by MTT. Our data showed that cisplatin led to cardiac-function deterioration, myocardial injury, increased lactate dehydrogenase, creatine kinase, malondialdehyde activities, and decreased activities of superoxide dismutase, glutathione, glutathione peroxidase, and catalase. Treatment with resveratrol effectively hindered the adverse effects of cisplatin in a dose-dependent manner, such as myocardial injury and impaired heart function. An in vitro cytotoxic study showed that resveratrol could increase the antineoplastic activity of cisplatin to A549 adenocarcinoma cells. All the above lines of evidence suggest that resveratrol protects cardiomyocytes from cisplatin-induced cardiotoxicity via the suppression of oxidative stress.
顺铂是一种有效的抗肿瘤药物，但其严重的不良反应限制了其临床应用。本研究旨在评估白藜芦醇对顺铂诱导的心脏损伤的作用。白藜芦醇是一种有效的自由基清除剂。在本研究中，我们测试了白藜芦醇是否能预防顺铂诱导的大鼠心脏毒性。检测了血浆酶活性和组织学心肌变化。通过 MTT 法检测白藜芦醇和/或顺铂的抗癌作用。我们的数据表明，顺铂导致心脏功能恶化、心肌损伤、乳酸脱氢酶、肌酸激酶、丙二醛活性增加，超氧化物歧化酶、谷胱甘肽、谷胱甘肽过氧化物酶和过氧化氢酶活性降低。白藜芦醇以剂量依赖的方式有效阻止了顺铂的不良影响，如心肌损伤和心脏功能受损。体外细胞毒性研究表明，白藜芦醇可以增加顺铂对 A549 腺癌细胞的抗癌活性。所有这些证据表明，白藜芦醇通过抑制氧化应激来保护心肌细胞免受顺铂诱导的心脏毒性。
