USDA/ARS Children's Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
Public Health Nutr. 2010 Oct;13(10):1587-92. doi: 10.1017/S1368980009993004. Epub 2009 Dec 22.
To examine the relationship of 6-n-propylthiouracil (PROP) sensitivity to BMI while statistically controlling for demographic characteristics in two age groups of children: 9-10 years and 17-18 years (n 1551).
Cross-sectional design with a multi-ethnic (White, African-American, Hispanic, Other) sample of 813 children aged 9-10 years and 738 children aged 17-18 years. Children were recruited from local elementary and high schools with at least 30 % minority ethnic enrolment. Children's height, weight and waist circumference were measured along with their PROP taster status. PROP was measured using two paper discs, one impregnated with NaCl (1.0 mol/l) and the other with PROP solution (0.50 mmol/l).
A significant PROP sensitivity by socio-economic status (SES) interaction term (P = 0.010) was detected wherein supertasters had the largest BMI percentile and Z-score, but only among the group with highest SES.
The results suggest that other factors overwhelmed the influence of PROP sensitivity on adiposity in lower-SES groups. The percentage of variance accounted for by the interaction term was about 1 %. Thus, PROP supertasters had the largest BMI percentile and Z-score, but only among the highest-SES group.
在控制两个年龄段（9-10 岁和 17-18 岁）儿童的人口统计学特征的情况下，研究 6-正丙基硫氧嘧啶（PROP）敏感性与 BMI 的关系（n=1551）。
具有多民族（白种人、非裔美国人、西班牙裔、其他）样本的横断面设计，其中包括 813 名 9-10 岁的儿童和 738 名 17-18 岁的儿童。儿童从至少有 30%少数民族入学的当地小学和中学招募。在儿童的PROP 味觉状态下，测量其身高、体重和腰围。PROP 使用两个浸渍有 NaCl（1.0mol/l）和 PROP 溶液（0.50mmol/l）的纸盘进行测量。
检测到社会经济地位（SES）交互项的显著 PROP 敏感性（P=0.010），其中超级味觉者的 BMI 百分位数和 Z 分数最大，但仅在 SES 最高的组中。
结果表明，其他因素在 SES 较低的群体中，压倒了 PROP 敏感性对肥胖的影响。交互项解释的方差百分比约为 1%。因此，PROP 超级味觉者的 BMI 百分位数和 Z 分数最大，但仅在 SES 最高的组中。
