姜黄素通过抑制 Akt-SREBP-1 通路抑制丙型肝炎病毒复制。
Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway.
机构信息
Department of Molecular Biology, College of Natural Sciences, Pusan National University, Busan, Republic of Korea.
出版信息
FEBS Lett. 2010 Feb 19;584(4):707-12. doi: 10.1016/j.febslet.2009.12.019. Epub 2009 Dec 17.
A polyphenolic compound from the curry spice turmeric, curcumin, is known to show anti-viral activity against the influenza virus, adenovirus, coxsackievirus, and the human immunodeficiency virus. However, it remains to be determined whether curcumin can inhibit the replication of hepatitis C virus (HCV). In this study, we showed that curcumin decreases HCV gene expression via suppression of the Akt-SREBP-1 activation, not by NF-kappaB pathway. The combination of curcumin and IFNalpha exerted profound inhibitory effects on HCV replication. Collectively, our results indicate that curcumin can suppress HCV replication in vitro and may be potentially useful as novel anti-HCV reagents.
姜黄（咖喱粉的主要成分）中的一种多酚化合物姜黄素，具有抗流感病毒、腺病毒、柯萨奇病毒和人类免疫缺陷病毒的活性。然而，姜黄素是否能抑制丙型肝炎病毒（HCV）的复制还需要进一步确定。在这项研究中，我们发现姜黄素通过抑制 Akt-SREBP-1 激活而非 NF-kappaB 途径来降低 HCV 基因表达。姜黄素和 IFNalpha 的联合使用对 HCV 复制有显著的抑制作用。综上所述，我们的结果表明姜黄素可以抑制 HCV 的体外复制，可能是一种新型的抗 HCV 试剂。
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