Cunha Leonardo Provetti, Costa-Cunha Luciana Virginia Ferreira, Malta Roberto Freire Santiago, Monteiro Mário Luiz Ribeiro
Clínica Oftalmológica, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brazil.
Arq Bras Oftalmol. 2009 Sep-Oct;72(5):622-5. doi: 10.1590/s0004-27492009000500004.
To compare the optical coherence tomography retinal nerve fiber layer and macular thickness measurements for detection of progressive axonal loss following acute traumatic optic neuropathy in a longitudinal study.
Three patients with unilateral traumatic optic neuropathy were evaluated sequentially after trauma. Macular and retinal nerve fiber layer thickness measurements were obtained using optical coherence tomography weekly for five weeks and around the twelfth week after trauma.
All patients showed progressive macular and retinal nerve fiber layer thickness reduction. The mean retinal nerve fiber layer thickness on the first week was 114 microm and reduced sequentially over the first five weeks and was 46 microm on the twelfth week. For macular parameters, the mean average thickness on the first week was 248 microm and also reduced over the first five weeks and was 218 microm on the twelfth week. When compared to the initial measurement, macular thickness average reduction rate at the 12th week was 14% while peripapillary retinal nerve fiber layer thickness average reduction rate was 59%.
Although both measurements reduce significantly after trauma, retinal nerve fiber layer thickness measurements show greater and faster retinal neural reduction if compared to macular thickness measurements in traumatic optic neuropathy.
在一项纵向研究中，比较光学相干断层扫描测量视网膜神经纤维层和黄斑厚度，以检测急性外伤性视神经病变后轴突的进行性损失。
对3名单侧外伤性视神经病变患者在受伤后进行连续评估。在受伤后的5周内每周使用光学相干断层扫描测量黄斑和视网膜神经纤维层厚度，并在受伤后约第12周进行测量。
所有患者均显示黄斑和视网膜神经纤维层厚度逐渐降低。第1周视网膜神经纤维层平均厚度为114微米，在最初的5周内依次降低，第12周时为46微米。对于黄斑参数，第1周平均厚度为248微米，在最初的5周内也降低，第12周时为218微米。与初始测量相比，第12周黄斑厚度平均降低率为14%，而视乳头周围视网膜神经纤维层厚度平均降低率为59%。
虽然受伤后两种测量值均显著降低，但在外伤性视神经病变中，与黄斑厚度测量相比，视网膜神经纤维层厚度测量显示视网膜神经减少程度更大、速度更快。
