从仙茅中提取的三萜糖苷及其细胞毒性。

Triterpene glycosides from Curculigo orchioides and their cytotoxic activity.

机构信息

Laboratory of Medicinal Pharmacognosy, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Horinouchi 1432-1, Hachiouji, Tokyo 192-0392, Japan.

出版信息

J Nat Prod. 2010 Jun 25;73(6):1102-6. doi: 10.1021/np100111s.

DOI:10.1021/np100111s

PMID:20524638

Abstract

Six new cycloartane glycosides (1-6) were isolated from the rhizomes of Curculigo orchioides. The structures of 1-6 were determined by spectroscopic analyses and the results of hydrolytic cleavage. Compounds 1-6, and their common aglycone (1a), were evaluated for cytotoxic activity against HL-60 human leukemia cells. Compounds 1 and 1a showed cytotoxic activity against HL-60 cells with IC(50) values of 9.0 and 1.8 microM, respectively. The cancer cell growth inhibition of 1a was also examined using a panel of 39 human cancer cell lines in the Japanese Foundation for Cancer Research.

摘要

从仙茅根茎中分离得到 6 个新的环阿尔廷甾烷糖苷（1-6）。通过光谱分析和水解裂解的结果确定了 1-6 的结构。对化合物 1-6 及其常见糖苷配基（1a）进行了对 HL-60 人白血病细胞的细胞毒性活性评价。化合物 1 和 1a 对 HL-60 细胞表现出细胞毒性活性，IC（50）值分别为 9.0 和 1.8 μM。还使用日本癌症研究基金会的 39 个人类癌细胞系的面板检查了 1a 的癌细胞生长抑制作用。